evidencegaps
Primary study · included by 1 review

Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial.

Hayakumo 2013 · Hayakumo Sae, Arakawa Shinichi, Mano Yoshihiro, et al. · Clinical oral investigations · 2013

Included by

Oxygen-Based Adjunct Therapies in Periodontitis: A Systematic Review and Meta-Analysis Within the Framework of Hypoxia and Inflammation.
Non-Cochrane · intervention · 2025 · cited as Hayakumo 2013 · Table 1; reference 25; Figure 2
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL) change from baseline to follow-up
Adjunct ozone therapy (gaseous ozone, ozonated water, ozonated olive oil) to subgingival instrumentation vs Subgingival instrumentation alone · 1 to 3 months after initial treatment
SMD 0.53 [-0.14, 1.19]7 studies · 292 participantsGRADE not reported

1 including review in total.