Primary study · included by 1 review

A comparison of the efficacy of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary teeth with irreversible pulpitis.

Kanaa 2012 · Kanaa Mohammad D, Whitworth John M, Meechan John G · Journal of endodontics · 2012

Included by

Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.

Non-Cochrane · intervention · 2026 · cited as Kanaa 2012 · Reference 18; Results (studies cited per outcome); Table 1

Outcome this study informs	Pooled effect	Evidence	Certainty
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.05 [0.9, 1.23]	3 studies	GRADE not reported
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -2.6 [-5.07, -0.12]	4 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -1.81 [-2.85, -0.78]	5 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.02 [0.94, 1.11]	9 studies	GRADE not reported
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -3.16 [-6.09, -0.23]	7 studies	GRADE not reported
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -2.38 [-3.43, -1.33]	3 studies	GRADE not reported
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -0.95 [-7.73, 5.84]	3 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.05 [0.93, 1.18]	10 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.03 [0.98, 1.08]	12 studies · 989 participants	Moderate
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.07 [0.93, 1.23]	2 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.04 [0.95, 1.13]	5 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.01 [0.88, 1.16]	5 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.03 [0.93, 1.15]	6 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -0.57 [-0.99, -0.16]	2 studies	GRADE not reported
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -4.41 [-7.62, -1.21]	7 studies · 418 participants	Moderate
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -5.2 [-8.01, -2.38]	3 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.04 [0.97, 1.12]	6 studies	GRADE not reported
Anesthetic onset time 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -1.34 [-2.21, -0.47]	7 studies · 705 participants	Low
Pain intensity (VAS) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -8.72 [-16.04, -1.4]	3 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -2.2 [-3.36, -1.03]	3 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -0.59 [-2.12, 0.95]	4 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.02 [0.98, 1.06]	10 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 0.99 [0.9, 1.09]	7 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.03 [0.96, 1.11]	9 studies	GRADE not reported

1 including review in total.