Primary study · included by 1 review

Articaine versus lidocaine for third molar surgery: a randomized clinical study.

Silva 2012 · Silva Luiz-Carlos-F, Santos Thiago-de-S, Santos Jadson-A S de-S, et al. · Medicina oral, patologia oral y cirugia bucal · 2012

Included by

Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.

Non-Cochrane · intervention · 2026 · cited as Silva 2012 · Reference 42; Results (studies cited per outcome); Table 1

Outcome this study informs	Pooled effect	Evidence	Certainty
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.12 [-0.19, -0.05]	3 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.24 [-0.39, -0.1]	5 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.25 [-0.39, -0.11]	8 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.97 [-1.77, -0.18]	5 studies	GRADE not reported
Anesthetic onset time 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.27 [-0.40, -0.13]	9 studies · 638 participants	Moderate
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.35 [-0.57, -0.12]	6 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.21 [-0.43, 0.01]	4 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -0.61 [-1.11, -0.1]	5 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia	MD -1.15 [-2.24, -0.07]	2 studies	GRADE not reported

1 including review in total.