evidencegaps
Primary study · included by 1 review

Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial.

Mehrvarzfar 2012 · Mehrvarzfar P, Abbott P V, Saghiri M A, et al. · International endodontic journal · 2012

Included by

Efficacy and safety of single-dose oral postoperative medications in reducing pain after endodontic treatment: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Mehrvarzfar 2012 · Table 2; Study characteristics
Outcome this study informsPooled effectEvidenceCertainty
Postoperative pain (VAS) at 6-8 h
Single-dose oral Naproxen after root canal treatment vs Placebo · 6-8 h after treatment
MD -2.62 [-3.97, -1.27]2 studiesModerate
Postoperative pain (VAS) at 6-8 h
Single-dose oral Novafen after root canal treatment vs Placebo · 6-8 h after treatment
MD -3.46 [-5.27, -1.65]1 studyModerate
Postoperative pain (VAS) at 6-8 h
Single-dose oral Tramadol after root canal treatment vs Placebo · 6-8 h after treatment
MD -1.22 [-2.61, 0.17]2 studiesLow
Postoperative pain (VAS) at 6-8 h
Any single-dose oral analgesic after root canal treatment (all drugs pooled) vs Placebo · 6-8 h after treatment
MD -2.032 [-2.687, -1.376]5 studiesGRADE not reported

1 including review in total.