Primary study · included by 1 review

Studies on the orientations of the mitochondrial redox carriers. I. Orientation of the hemes of cytochrome c oxidase with respect to the plane of a cytochrome oxidase-lipid model membrane.

Afkhami 2023 · Erecińska M, Wilson D F, Blasie J K · Biochimica et biophysica acta · 1978

Included by

Evaluation of the effectiveness of local anesthesia approaches for symptomatic irreversible pulpitis: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2025 · cited as Afkhami 2023 · Table 1; Figure 3

Outcome this study informs	Pooled effect	Evidence	Certainty
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.62 [2.91, 4.27]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.34 [2.49, 4.48]	16 studies	High
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.26 [1.70, 6.28]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.36 [1.44, 7.85]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 4.31 [3.59, 5.17]	6 studies	High
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.79 [3.24, 4.44]	16 studies	GRADE not reported

1 including review in total.