evidencegaps
Primary study · included by 1 review

Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial.

Pradeep and Thorat 2010 · Pradeep Avani R, Thorat Manojkumar S · Journal of periodontology · 2010

Included by

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Pradeep 2010 · Figures 2-4; Tables 4-5 and reference list
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL), change from baseline (mm)
SRP plus locally delivered 1.2% simvastatin gel vs SRP alone (placebo gel or no gel) · 6 months
MD 2.17 [1.68, 2.66]4 studies · 228 participantsGRADE not reported
Probing pocket depth (PPD), change from baseline (mm)
SRP plus locally delivered 1.2% simvastatin gel vs SRP alone (placebo gel or no gel) · 6 months
MD 2.34 [1.65, 3.03]4 studies · 228 participantsGRADE not reported

1 including review in total.