evidencegaps
Primary study · included by 1 review

Abnormal brain structure in children with isolated clefts of the lip or palate.

Nopoulos 2007 · Nopoulos Peg, Langbehn Douglas R, Canady John, et al. · Archives of pediatrics & adolescent medicine · 2007

Included by

A Review and Meta-Analysis on Altered Brain Structure in Patients Born with Non-Syndromic Cleft Lip and/or Palate.
Non-Cochrane · aetiology · 2026 · cited as Nopoulos 2007 · Table 1; Figure 2
Outcome this study informsPooled effectEvidenceCertainty
Intracranial volume
Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional
SMD (Hedges' g) -0.36 [-0.65, -0.08]4 studies · 292 participantsGRADE not reported
Total cerebral volume
Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional
SMD (Hedges' g) 0.0 [-0.38, 0.39]4 studies · 347 participantsGRADE not reported
Total cerebellar volume
Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional
SMD (Hedges' g) -0.69 [-0.84, -0.53]6 studies · 667 participantsGRADE not reported

1 including review in total.