evidencegaps
Primary study · included by 1 review

Treatment of periodontitis and endothelial function.

Tonetti 2007 · Tonetti Maurizio S, D'Aiuto Francesco, Nibali Luigi, et al. · The New England journal of medicine · 2007

Included by

Periodontitis, Endothelial Dysfunction, and Systemic Inflammation: A Systematic Review and Meta-Analysis of Flow-Mediated Dilation.
Non-Cochrane · intervention · 2026 · cited as Tonetti 2007 · Table 1; Results 3.7
Outcome this study informsPooled effectEvidenceCertainty
Endothelial function: brachial artery flow-mediated dilation (FMD, percentage points)
Periodontal therapy (non-surgical, scaling and root planing, or intensive protocols) vs Control or standard care, less intensive therapy, or baseline (within-subject) · Short to intermediate follow-up (24 h to 12 months across studies)
MD 3.3 [1.7, 4.9]6 studies · 340 participantsModerate
Endothelial function: brachial artery flow-mediated dilation (FMD, percentage points)
Periodontal therapy (non-surgical, scaling and root planing, or intensive protocols) vs Control or standard care, less intensive therapy, or baseline (within-subject) · Short to intermediate follow-up (24 h to 12 months across studies)
Sensitivity analyses restricted to randomized controlled trials showed a smaller and non-significant effect on FMD (numeric estimate not reported)NRGRADE not reported

1 including review in total.