Primary study · included by 1 review
A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus.
Yoke 2006 · Yoke Poon Choy, Tin Goh Bee, Kim Myung-Jin, et al. · Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2006
Included by
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
Pain severity (VAS 0-10) Topical steroids (clobetasol, betamethasone, triamcinolone) vs Other treatments in the network · 4 weeks | SUCRA 61 | 5 studies · 275 participants | GRADE not reported |
Pain severity (VAS 0-10) Topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporin) vs Topical steroids (clobetasol, betamethasone, triamcinolone) · 4 weeks (follow-up weeks 3-4) | MD -0.06 [-0.55, 0.44] | 5 studies · 276 participants | Moderate |
Adverse effect: transient burning Topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporin) vs Topical steroids (clobetasol, betamethasone, triamcinolone) · First 2 days of treatment | OR 2.45 [0.55, 10.85] | 4 studies · 247 participants | High |
Pain severity (VAS 0-10) Placebo vs Other treatments in the network · 4 weeks | SUCRA 13.74 | 5 studies · 275 participants | GRADE not reported |
Pain severity (VAS 0-10) Topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporin) vs Topical steroids (clobetasol, betamethasone, triamcinolone) · 4 weeks | MD -0.11 [-0.97, 0.62] | 5 studies · 275 participants | GRADE not reported |
Pain severity (VAS 0-10) Topical calcineurin inhibitors (tacrolimus, pimecrolimus, cyclosporin) vs Other treatments in the network · 4 weeks | SUCRA 75.27 | 5 studies · 275 participants | GRADE not reported |
1 including review in total.