Primary study · included by 1 review

Structural brain abnormalities in adult males with clefts of the lip and/or palate.

Nopoulos 2002 · Nopoulos Peg, Berg Stephanie, Canady John, et al. · Genetics in medicine : official journal of the American College of Medical Genetics · 2002

Included by

A Review and Meta-Analysis on Altered Brain Structure in Patients Born with Non-Syndromic Cleft Lip and/or Palate.

Non-Cochrane · aetiology · 2026 · cited as Nopoulos 2002 · Table 1; Figure 2

Outcome this study informs	Pooled effect	Evidence	Certainty
Intracranial volume Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional	SMD (Hedges' g) -0.36 [-0.65, -0.08]	4 studies · 292 participants	GRADE not reported
Total cerebral volume Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional	SMD (Hedges' g) 0.0 [-0.38, 0.39]	4 studies · 347 participants	GRADE not reported
Cortical gray matter volume Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional	SMD (Hedges' g) -0.08 [-0.51, 0.34]	2 studies · 116 participants	GRADE not reported
Total cerebellar volume Presence of NSCL/P (exposure) vs Unaffected healthy controls · Cross-sectional	SMD (Hedges' g) -0.69 [-0.84, -0.53]	6 studies · 667 participants	GRADE not reported

1 including review in total.