Primary study · included by 1 review

Huang 1999

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Inflammatory Biomarkers in Irreversible Pulpitis and Pulp Necrosis: A Systematic Review and Meta-Analysis.

Non-Cochrane · aetiology · 2026 · cited as Huang 1999 · Table 1; Fig 2, Fig 3 and Supplementary Figures

Outcome this study informs	Pooled effect	Evidence	Certainty
IL-8 level in dental pulp Symptomatic irreversible pulpitis (exposure) vs Healthy pulp	SMD -1.86 [-2.42, -1.3]	6 studies · 243 participants	Low
IL-8 level in dental pulp Symptomatic irreversible pulpitis (exposure) vs Healthy pulp	SMD -1.9 [-4.13, 0.34]	2 studies · 65 participants	GRADE not reported
IL-8 level in dental pulp Symptomatic irreversible pulpitis (exposure) vs Healthy pulp	SMD -1.96 [-2.89, -1.02]	4 studies · 142 participants	GRADE not reported
IL-8 level Symptomatic irreversible pulpitis (SIP) vs Healthy pulp · Single time point (biomarker level at diagnosis/sampling)	SMD -1.95 [-2.64, -1.26]	5 studies · 203 participants	GRADE not reported

1 including review in total.