Primary study · included by 1 review

Dumoulin 2020

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Identifying risk factors for osteoradionecrosis of the jaws: a systematic review and meta-analysis.
Non-Cochrane · aetiology · 2026 · cited as Dumoulin 2020 · Fig. 2-5 forest plot; Table 1
Outcome this study informsPooled effectEvidenceCertainty
Osteoradionecrosis of the jaws (ORNJ)
Oral cavity cancer (tumor site) (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 4.81 [1.56, 14.9]4 studies · 6872 participantsGRADE not reported
Development of osteoradionecrosis of the jaws (ORNJ)
Oropharyngeal tumor vs Non-oropharyngeal tumor
OR 2.61 [0.32, 21.52]3 studies · 1810 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Oropharyngeal tumor (tumor site) (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 2.34 [1.63, 3.34]3 studies · 1810 participantsModerate
Osteoradionecrosis of the jaws (ORNJ)
Oropharyngeal tumor (tumor site) (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 2.61 [0.32, 21.52]3 studies · 1810 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction (any timing) (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 23.88 [0.2, 2869.91]2 studies · 1629 participantsGRADE not reported
Development of osteoradionecrosis of the jaws (ORNJ)
Diabetes mellitus vs No diabetes mellitus
OR 1.01 [0.86, 1.19]7 studies · 23068 participantsModerate
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction after radiotherapy (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 8.38 [7.2, 9.77]3 studies · 17508 participantsModerate
Osteoradionecrosis of the jaws (ORNJ)
Diabetes mellitus (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 1.01 [0.86, 1.19]7 studies · 23068 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tobacco use (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 2.18 [0.73, 6.49]7 studies · 3422 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tobacco use (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 2.56 [1.96, 3.34]7 studies · 3422 participantsModerate
Osteoradionecrosis of the jaws (ORNJ)
Tobacco use (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 3.44 [1.22, 9.73]7 studies · 3930 participantsGRADE not reported
Development of osteoradionecrosis of the jaws (ORNJ)
Oral cancer (oral cavity tumor site) vs No oral cancer (other tumor sites)
OR 4.81 [1.56, 14.9]4 studies · 6872 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction before radiotherapy (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 1.15 [1.01, 1.31]4 studies · 17674 participantsModerate
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction after radiotherapy (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 8.5 [7.34, 9.85]3 studies · 18315 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction before radiotherapy (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 0.98 [0.67, 1.45]4 studies · 17674 participantsGRADE not reported
Development of osteoradionecrosis of the jaws (ORNJ)
Diabetes mellitus vs No diabetes mellitus
OR 1.01 [0.86, 1.19]7 studies · 23068 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction after radiotherapy (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 8.32 [7.15, 9.7]3 studies · 17508 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Oral cavity cancer (tumor site) (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 4 [2.9, 5.51]4 studies · 6872 participantsModerate
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction before radiotherapy (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 1.09 [0.75, 1.58]4 studies · 17840 participantsGRADE not reported
Osteoradionecrosis of the jaws (ORNJ)
Tooth extraction (any timing) (frequency among patients who developed ORNJ) vs Same factor among irradiated patients who did not develop ORNJ · Not specified
OR 12.31 [6.4, 23.69]2 studies · 1629 participantsModerate

1 including review in total.