Primary study · included by 1 review

De Santis 2022

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Efficacy of engineered scaffolds for horizontal and vertical ridge augmentation: A systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as De Santis 2022 · Supplement Table S3; Figure 1

Outcome this study informs	Pooled effect	Evidence	Certainty
Late complications (>=4 weeks), % Engineered (CAD/CAM customized) scaffold, mainly customized CAD/CAM titanium mesh with bone graft vs None (single-arm pooled mean; no between-scaffold comparison) · >= 4 weeks after surgery	Pooled proportion 18.0 [7.5, 28.4]	3 studies · 52 participants	GRADE not reported
Late complications (>=4 weeks), % Engineered (CAD/CAM customized) scaffold, mainly customized CAD/CAM titanium mesh with bone graft vs None (single-arm pooled mean; no between-scaffold comparison) · >= 4 weeks after surgery	Pooled proportion 16.5 [7.3, 25.7]	3 studies · 61 participants	Low
Early complications (<4 weeks), % Engineered (CAD/CAM customized) scaffold, mainly customized CAD/CAM titanium mesh with bone graft vs None (single-arm pooled mean; no between-scaffold comparison) · < 4 weeks after surgery	Pooled proportion 21.4 [10.1, 32.6]	3 studies · 51 participants	GRADE not reported
Horizontal bone gain (mm) Customized CAD/CAM titanium mesh · 4–10 months	MEAN 4.96 [4.48, 5.44]	3 studies · 77 participants	Moderate
Early complications (<4 weeks), % Engineered (CAD/CAM customized) scaffold, mainly customized CAD/CAM titanium mesh with bone graft vs None (single-arm pooled mean; no between-scaffold comparison) · < 4 weeks after surgery	Pooled proportion 24.3 [17.8, 30.8]	6 studies · 123 participants	Low
Horizontal bone gain (mm) Customized CAD/CAM titanium mesh with resorbable membrane	MEAN 5.64 [5.02, 6.26]	2 studies · 55 participants	GRADE not reported
Vertical bone gain (mm) Customized CAD/CAM titanium mesh without resorbable membrane	MEAN 6.36 [5.96, 6.76]	2 studies · 50 participants	GRADE not reported
Vertical bone gain (mm) Customized CAD/CAM titanium mesh with resorbable membrane	MEAN 4.26 [3.62, 4.9]	3 studies · 95 participants	GRADE not reported

1 including review in total.