Primary study · included by 1 review

Castillo-Silva 2019

ProbableThe reviews cited this study without a PMID, DOI or NCT, so it is matched by first author and year. Two different studies by the same author in the same year could be merged here.

Included by

Inflammatory Biomarkers in Irreversible Pulpitis and Pulp Necrosis: A Systematic Review and Meta-Analysis.

Non-Cochrane · aetiology · 2026 · cited as Castillo-Silva 2019 · Table 1; Fig 2, Fig 3 and Supplementary Figures

Outcome this study informs	Pooled effect	Evidence	Certainty
CGRP level in dental pulp Symptomatic irreversible pulpitis (exposure) vs Healthy pulp	SMD -2.4 [-3.41, -1.38]	7 studies · 222 participants	Low
CGRP level in dental pulp Symptomatic irreversible pulpitis (exposure) vs Healthy pulp	SMD -2.17 [-4.11, -0.23]	2 studies · 18 participants	GRADE not reported
CGRP level Symptomatic irreversible pulpitis (SIP) vs Healthy pulp · Single time point (biomarker level at diagnosis/sampling)	SMD -1.39 [-1.87, -0.9]	7 studies · 222 participants	GRADE not reported
CGRP level in dental pulp Symptomatic irreversible pulpitis (exposure) vs Healthy pulp	SMD -1.07 [-1.74, -0.4]	3 studies · 104 participants	GRADE not reported

1 including review in total.