evidencegaps
Primary study · included by 1 review

Efficacy of ibuprofen and paracetamol and diclofenac sodium and paracetamol combination on postoperative pain following root canal preparation in a randomized placebo-controlled study

Makkar 2012 · Kaler Nisha, Makkar Sameer, Mann Navjot, et al. · Indian Journal of Oral Sciences · 2012

Included by

Efficacy and safety of single-dose oral postoperative medications in reducing pain after endodontic treatment: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Makkar 2012 · Table 2; Study characteristics
Outcome this study informsPooled effectEvidenceCertainty
Postoperative pain (VAS) at 6-8 h
Single-dose oral Diclofenac + Acetaminophen after root canal treatment vs Placebo · 6-8 h after treatment
MD -6.28 [-11.99, -0.56]1 studyModerate
Postoperative pain (VAS) at 6-8 h
Any single-dose oral analgesic after root canal treatment (all drugs pooled) vs Placebo · 6-8 h after treatment
MD -2.032 [-2.687, -1.376]5 studiesGRADE not reported
Postoperative pain (VAS) at 6-8 h
Single-dose oral Ibuprofen + Acetaminophen after root canal treatment vs Placebo · 6-8 h after treatment
MD -3.05 [-4.80, -1.30]2 studiesModerate

1 including review in total.