Primary study · included by 1 review

Picardo 2020

Included by

Serum vitamin D Levels in patients with medication-related osteonecrosis of the jaw: a systematic review and meta-analysis.

Non-Cochrane · aetiology · 2026 · cited as Picardo 2020 · Table 1; Fig. 2; reference list

Outcome this study informs	Pooled effect	Evidence	Certainty
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	SMD -0.13 [-0.47, 0.21]	3 studies · 203 participants	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) 0.0214	NR	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	SMD 0.40 [-0.37, 1.16]	2 studies · 136 participants	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	SMD -0.06 [-0.51, 0.39]	6 studies · 359 participants	Very low
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) 0.0660	NR	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) 0.0196	3 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level (standardized mean difference) Presence of medication-related osteonecrosis of the jaw (MRONJ cases) vs Antiresorptive-exposed individuals without MRONJ (controls) · Post-diagnosis	SMD -0.09 [-0.64, 0.46]	5 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) 0.0352	NR	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Pooled mean (ng/mL) 36.86	6 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) -0.0078	NR	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) -0.4270	NR	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level (standardized mean difference) Presence of medication-related osteonecrosis of the jaw (MRONJ cases) vs Antiresorptive-exposed individuals without MRONJ (controls) · Post-diagnosis	SMD 0.02 [-0.48, 0.52]	5 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) 0.6677	3 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level (standardized mean difference) Presence of medication-related osteonecrosis of the jaw (MRONJ cases) vs Antiresorptive-exposed individuals without MRONJ (controls) · Post-diagnosis	SMD -0.11 [-0.66, 0.44]	5 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	SMD -0.11 [-0.36, 0.15]	4 studies · 266 participants	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) -1.2602	NR	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) -0.3946	3 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	SMD 0.09 [-0.31, 0.49]	5 studies · 339 participants	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	SMD -0.21 [-0.57, 0.14]	5 studies · 286 participants	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Pooled mean (ng/mL) 33.16	6 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) -0.0592	3 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level (standardized mean difference) Presence of medication-related osteonecrosis of the jaw (MRONJ cases) vs Antiresorptive-exposed individuals without MRONJ (controls) · Post-diagnosis	SMD -0.09 [-0.64, 0.47]	5 studies	GRADE not reported
Serum 25-hydroxyvitamin D [25(OH)D] level Presence of MRONJ (exposure) vs Antiresorptive-exposed individuals without MRONJ · Post-diagnosis (single prespecified time point per study)	Meta-regression coefficient (B) 0.0006	NR	GRADE not reported

1 including review in total.