evidencegaps
Primary study · included by 1 review

Cytotoxicity evaluation of different clear aligner systems on human primary gingival fibroblasts: an in vitro study

Das 2026 · Das Rituparna Pronajit, Gangurde Parag Vishnu, Ranjan Alok, et al. · Biomaterial Investigations in Dentistry · 2026

Included by

From Polyethylene Terephthalate Glycol (PETG) to 3D-Printed Resins: A Systematic Review and Meta-Analysis of Clear Aligner Material Performance and Safety.
Non-Cochrane · intervention · 2026 · cited as Das 2026 · Table 4; reference [16]
Outcome this study informsPooled effectEvidenceCertainty
Cytotoxicity classification
Clear aligner materials
Proportion (%) 21.4 [8.8, 43.5]2 studiesGRADE not reported
Cytotoxicity event rate (logit)
Thermoplastic aligner materials (PETG, PET, PU) tested on human gingival cells vs No comparator (single-group event rate) · Not applicable
Logit event rate -1.30 [-2.34, -0.26]2 studiesGRADE not reported

1 including review in total.