evidencegaps
Primary study · included by 2 reviews

A Randomized, Double-Blind, Placebo-Controlled Trial on Clinical Efficacy of Topical Agents in Reducing Pain and Frequency of Recurrent Aphthous Ulcers

Sharma 2018 · Sharma Renu, Pallagatti Shambulingappa, Aggarwal Amit, et al. · The Open Dentistry Journal · 2018

Included by

Effectiveness of 0.1% triamcinolone acetonide compared with those of other therapies for minor recurrent aphthous stomatitis: a systematic review and meta-analysis of randomized controlled trials.
Non-Cochrane · intervention · 2025 · cited as Sharma 2018 · Table 2; reference 47

The review does not say which of its outcomes this study informs.

Bridging Conventional and Natural Therapies for Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis of Triamcinolone and Non-Steroidal Alternatives
Non-Cochrane · intervention · 2026 · cited as Sharma 2018 · Table 2; Figure 2; reference 52
Outcome this study informsPooled effectEvidenceCertainty
VAS pain score
Synthetic topical interventions (hyaluronic acid, amlexanox, triester glycerol oxide, Ora-Aid) vs Topical triamcinolone · Post-treatment, about 5 to 10 days
SMD 0.58 [0.35, 0.81]5 studiesGRADE not reported
Pain (VAS)
Synthetic topical interventions (hyaluronic acid, amlexanox, triester glycerol oxide, Ora-Aid) vs Topical triamcinolone
SMD 0.25 [-0.33, 0.83]6 studies · 366 participantsGRADE not reported
VAS pain score
Any non-steroidal topical or alternative therapy (natural and synthetic combined) vs Topical triamcinolone · Post-treatment, about 5 to 10 days
SMD 0.48 [0.22, 0.73]13 studiesGRADE not reported
Pain (VAS)
Alternative topical agents (natural and synthetic, pooled across interventions) vs Topical triamcinolone
SMD 0.37 [0.04, 0.69]14 studies · 836 participantsGRADE not reported
Pain (VAS)
Amlexanox vs Topical triamcinolone
SMD -0.43 [-1.89, 1.03]2 studies · 80 participantsGRADE not reported

2 including reviews in total.