Primary study · included by 1 review
Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial
Kamel 2022 · Kamel Asem, Abdelrahman Ahmed, Gobran Hany, et al. · Egyptian Journal of Oral and Maxillofacial Surgery · 2021
Included by
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
Bone fill (BF) Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined) | SMD 2.29 | NR | GRADE not reported |
Clinical attachment level (CAL) gain Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined) | SMD 1.91 | NR | GRADE not reported |
Clinical attachment level (CAL) gain Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined) | SMD 0.99 | NR | GRADE not reported |
Clinical attachment level (CAL) gain Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined) | SMD 1.91 [1.37, 2.46] | 4 studies | GRADE not reported |
Bone fill (BF) Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined) | SMD 2.29 [2.15, 2.44] | 4 studies | GRADE not reported |
Bone fill (BF) Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined) | SMD 2.07 | NR | GRADE not reported |
1 including review in total.