evidencegaps
Primary study · included by 1 review

Effects of honey-lemon spray on recurrent aphthous stomatitis comparing to Triamcinolone ointment

Shirzaiy 2023 · Shirzaiy Masoomeh, Heydarirad Ghazaleh, Bakhshipour Samaneh · Brazilian Journal of Oral Sciences · 2023

Included by

Bridging Conventional and Natural Therapies for Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis of Triamcinolone and Non-Steroidal Alternatives
Non-Cochrane · intervention · 2026 · cited as Shirzaiy 2023 · Table 2; Figure 2; reference 44
Outcome this study informsPooled effectEvidenceCertainty
Pain (VAS)
Honey-based therapies (honey, thyme honey, honey-lemon) vs Topical triamcinolone
SMD 0.33 [-0.28, 0.95]4 studies · 260 participantsGRADE not reported
VAS pain score
Any non-steroidal topical or alternative therapy (natural and synthetic combined) vs Topical triamcinolone · Post-treatment, about 5 to 10 days
SMD 0.48 [0.22, 0.73]13 studiesGRADE not reported
Pain (VAS reduction from baseline)
Natural topical interventions (honey preparations, curcumin, Punica granatum, Rhus coriaria, HiOra SG, honey-lemon) vs Topical triamcinolone
SMD 0.44 [0.03, 0.85]8 studies · 470 participantsGRADE not reported
Pain (VAS)
Alternative topical agents (natural and synthetic, pooled across interventions) vs Topical triamcinolone
SMD 0.37 [0.04, 0.69]14 studies · 836 participantsGRADE not reported

1 including review in total.