evidencegaps
Primary study · included by 2 reviews

The Efficacy of Hyaluronic Acid Gel in Pain Control of Recurrent Aphthous Stomatitis

Koray 2016 · M Koray, D Ofluoglu, A Senemtasi, et al. · International Journal of Dentistry and Oral Science · 2016

Included by

Effectiveness of 0.1% triamcinolone acetonide compared with those of other therapies for minor recurrent aphthous stomatitis: a systematic review and meta-analysis of randomized controlled trials.
Non-Cochrane · intervention · 2025 · cited as Koray 2016 · Table 2; reference 49

The review does not say which of its outcomes this study informs.

Bridging Conventional and Natural Therapies for Recurrent Aphthous Stomatitis: A Systematic Review and Meta-Analysis of Triamcinolone and Non-Steroidal Alternatives
Non-Cochrane · intervention · 2026 · cited as Koray 2016 · Table 2; Figure 2; reference 47
Outcome this study informsPooled effectEvidenceCertainty
VAS pain score
Synthetic topical interventions (hyaluronic acid, amlexanox, triester glycerol oxide, Ora-Aid) vs Topical triamcinolone · Post-treatment, about 5 to 10 days
SMD 0.58 [0.35, 0.81]5 studiesGRADE not reported
Pain (VAS)
Synthetic topical interventions (hyaluronic acid, amlexanox, triester glycerol oxide, Ora-Aid) vs Topical triamcinolone
SMD 0.25 [-0.33, 0.83]6 studies · 366 participantsGRADE not reported
VAS pain score
Any non-steroidal topical or alternative therapy (natural and synthetic combined) vs Topical triamcinolone · Post-treatment, about 5 to 10 days
SMD 0.48 [0.22, 0.73]13 studiesGRADE not reported
Pain (VAS)
Alternative topical agents (natural and synthetic, pooled across interventions) vs Topical triamcinolone
SMD 0.37 [0.04, 0.69]14 studies · 836 participantsGRADE not reported
Pain (VAS)
Hyaluronic acid vs Topical triamcinolone
SMD 0.70 [0.35, 1.04]2 studies · 137 participantsGRADE not reported

2 including reviews in total.