evidencegaps
Primary study · included by 1 review

Impact of the Daily Use of a Microcrystal Hydroxyapatite Dentifrice on De Novo Plaque Formation and Clinical/Microbiological Parameters of Periodontal Health. A Randomized Trial

Harks 2016 · Harks Inga, Jockel-Schneider Yvonne, Schlagenhauf Ulrich, et al. · PLOS ONE · 2016

Included by

Natural Agents for the Improvement of Gingival Health: Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Non-Cochrane · intervention · 2026 · cited as Harks 2016 · Table 1; Figure 2; reference list
Outcome this study informsPooled effectEvidenceCertainty
Gingival health (bleeding on probing, or gingival index when BoP not reported)
Natural-ingredient toothpastes and gels (e.g., Aloe vera, Pudilan, hydroxyapatite, herbal extracts) vs Control toothpastes and gels (placebo or active control) · 12 weeks to 6 months
MD 0.63 [0.19, 1.07]10 studiesGRADE not reported

1 including review in total.