evidencegaps
Primary study · included by 1 review

The Role of Chronic Exposure to Amoxicillin/Clavulanic Acid on the Developmental Enamel Defects in Mice

Mihalas 2016 · Mihalaş Eugeniu, Matricala Lavinia, Chelmuş Alina, et al. · Toxicologic Pathology · 2015

Included by

Effects of Antibiotics and Anti-Inflammatory Drugs on Enamel Development: A Systematic Review with Quantitative Synthesis.
Non-Cochrane · intervention · 2026 · cited as Mihalas 2016 · Table 2; reference list; Fig. 2/Fig. 3; Supplementary Table S2
Outcome this study informsPooled effectEvidenceCertainty
Enamel phosphorus content
Antibiotics (amoxicillin, amoxicillin plus clavulanate, erythromycin) and anti-inflammatory drugs (celecoxib, indomethacin, ibuprofen, acetaminophen) vs No medication (control) · Exposure during enamel development
SMD (Cohen's d) 0.46 [-0.31, 1.75]4 studiesGRADE not reported
Enamel calcium content
Antibiotics (amoxicillin, amoxicillin plus clavulanate, erythromycin) and anti-inflammatory drugs (celecoxib, indomethacin, ibuprofen, acetaminophen) vs No medication (control) · Exposure during enamel development
SMD (Cohen's d) 0.52 [-0.21, 1.46]4 studiesGRADE not reported

1 including review in total.