evidencegaps
Primary study · included by 1 review

Biochemical analysis of callus tissue in osteogenesis imperfecta type IV. Evidence for transient overmodification in collagen types I and III.

Brenner 1989 · Brenner R E, Vetter U, Nerlich A, et al. · Journal of Clinical Investigation · 1989

Included by

Post-translational modifications of collagen type I in osteogenesis imperfecta: Systematic review and meta-analysis.
Non-Cochrane · other · 2026 · cited as Brenner 1989 · Table 3; Supplementary material 2 (meta-analysis reference list)
Outcome this study informsPooled effectEvidenceCertainty
Ratio of hydroxylysine to hydroxyproline (HYL/HYP) in collagen-I
OI collagen-I (patient-derived bone, fibroblast or dentine samples) vs Control (healthy) collagen-I
Normalized mean difference 0.22 [0.19, 0.25]10 studies · 96 participantsGRADE not reported

1 including review in total.