Primary study · included by 2 reviews

Effect of different platelet‐rich fibrin matrices for ridge preservation in multiple tooth extractions: A split‐mouth randomized controlled clinical trial

Castro et al., 2021 · Castro Ana B., Van Dessel Jeroen, Temmerman Andy, et al. · Journal of Clinical Periodontology · 2021

Included by

The efficacy of platelet-rich fibrin in alveolar ridge preservation: a systematic review and meta-analysis of randomized controlled trials.

Non-Cochrane · intervention · 2026 · cited as Castro 2021 · Table 1; reference 15; Figures 3-11

Outcome this study informs	Pooled effect	Evidence	Certainty
Alveolar ridge width reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 6 months	MD -0.11 [-0.41, 0.18]	2 studies · 110 participants	GRADE not reported
Percentage of new bone formation (BV/TV, histomorphometry) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 2 months	MD 22.11 [-10.27, 54.49]	2 studies · 74 participants	GRADE not reported
Alveolar ridge height reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 4 months	MD -0.57 [-0.93, -0.20]	5 studies · 122 participants	GRADE not reported
Percentage of new bone formation (BV/TV, histomorphometry) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 2 to 4 months (pooled over time points)	MD 15.92 [1.87, 29.97]	7 studies · 237 participants	Low
Alveolar ridge width reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 4 months	MD -0.23 [-0.66, 0.20]	5 studies · 122 participants	GRADE not reported
Alveolar ridge width reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 2 months	MD -0.62 [-1.18, -0.05]	2 studies · 41 participants	GRADE not reported
Alveolar ridge height reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 2 to 6 months (pooled over time points)	MD -0.60 [-0.85, -0.34]	13 studies · 457 participants	Moderate
Percentage of new bone formation (BV/TV, histomorphometry) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 3 months	MD 11.36 [4.70, 18.02]	3 studies · 83 participants	GRADE not reported
Percentage of new bone formation (BV/TV, histomorphometry) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 4 months	MD 16.97 [4.14, 29.81]	2 studies · 80 participants	GRADE not reported
Alveolar ridge width reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot)	MD -0.47 [-0.74, -0.21]	14 studies · 478 participants	GRADE not reported
Alveolar ridge height reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 6 months	MD -0.28 [-0.53, -0.03]	2 studies · 110 participants	GRADE not reported
Alveolar ridge width reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 3 months	MD -0.77 [-1.56, 0.03]	6 studies · 225 participants	GRADE not reported
Alveolar ridge width reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 2 to 6 months (pooled over time points)	MD -0.42 [-0.68, -0.16]	15 studies · 498 participants	Low
Percentage of new bone formation (BV/TV, histomorphometry) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot)	MD 17.07 [1.96, 32.19]	6 studies · 217 participants	GRADE not reported
Alveolar ridge height reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot) · 3 months	MD -0.95 [-1.59, -0.31]	6 studies · 225 participants	GRADE not reported
Alveolar ridge height reduction (mm) PRF alone placed in the extraction socket (any preparation protocol) vs Spontaneous healing (blood clot)	MD -0.57 [-0.82, -0.32]	12 studies · 437 participants	GRADE not reported

Effectiveness of platelet-rich fibrin concentrates in alveolar ridge preservation after tooth extraction: A systematic review of randomized clinical trials with tomographic evaluation.

Non-Cochrane · intervention · 2026 · cited as Castro et al., 2021 · Table 2; References

The review does not say which of its outcomes this study informs.

2 including reviews in total.