evidencegaps
Primary study · included by 1 review

Amoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats

de Souza 2016 · de Souza Juliana Feltrin, Gramasco Marina, Jeremias Fabiano, et al. · International Journal of Paediatric Dentistry · 2015

Included by

Effects of Antibiotics and Anti-Inflammatory Drugs on Enamel Development: A Systematic Review with Quantitative Synthesis.
Non-Cochrane · intervention · 2026 · cited as de Souza 2016 · Table 2; reference list; Fig. 2/Fig. 3; Supplementary Table S2
Outcome this study informsPooled effectEvidenceCertainty
Enamel thickness
Amoxicillin, amoxicillin plus clavulanate, or amoxicillin plus NaF vs No medication (control) · Exposure during enamel development
SMD (Cohen's d) 0.79 [0.40, 1.36]5 studiesGRADE not reported

1 including review in total.