Substitution of serine for glycine 883 in the triple helix of the pro alpha 1 (I) chain of type I procollagen produces osteogenesis imperfecta type IV and introduces a structural change in the triple helix that does not alter cleavage of the molecule by procollagen N-proteinase.

Lightfoot 1994 · Lightfoot S J, Atkinson M S, Murphy G, et al. · Journal of Biological Chemistry · 1994