Primary study · included by 1 review

Anesthetic Efficacy of Combinations of 0.5 mol/L Mannitol and Lidocaine with Epinephrine for Inferior Alveolar Nerve Blocks in Patients with Symptomatic Irreversible Pulpitis

Kreimer 2012 · Kreimer Timothy, Kiser Russell, Reader Al, et al. · Journal of Endodontics · 2012

Included by

Evaluation of the effectiveness of local anesthesia approaches for symptomatic irreversible pulpitis: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2025 · cited as Kreimer 2012 · Table 1; Figure 3

Outcome this study informs	Pooled effect	Evidence	Certainty
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.62 [2.91, 4.27]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.34 [2.49, 4.48]	16 studies	High
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.26 [1.70, 6.28]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.36 [1.44, 7.85]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 4.31 [3.59, 5.17]	6 studies	High
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.79 [3.24, 4.44]	16 studies	GRADE not reported

1 including review in total.