Primary study · included by 1 review

Comparative Evaluation of 1.8 mL and 3.6 mL of 2% Lidocaine with 1:200,000 Epinephrine for Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis: A Prospective, Randomized Single-blind Study

Aggarwal 2012 · Aggarwal Vivek, Singla Mamta, Miglani Sanjay, et al. · Journal of Endodontics · 2012

Included by

Evaluation of the effectiveness of local anesthesia approaches for symptomatic irreversible pulpitis: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2025 · cited as Aggarwal 2012 · Table 1; Figure 3

Outcome this study informs	Pooled effect	Evidence	Certainty
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.62 [2.91, 4.27]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.34 [2.49, 4.48]	16 studies	High
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.26 [1.70, 6.28]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.36 [1.44, 7.85]	3 studies	GRADE not reported
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 4.31 [3.59, 5.17]	6 studies	High
Anesthesia success (adequate pain control during endodontic treatment) Modified anesthetic protocols (articaine, supplemental infiltrations, additives, increased volume) vs Conventional inferior alveolar nerve block (IANB) with 2% lidocaine with epinephrine · During endodontic treatment	OR 3.79 [3.24, 4.44]	16 studies	GRADE not reported

1 including review in total.