Primary study · included by 2 reviews

Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial

Işık 2022 · Işık Gözde, Kenç Selin, Özveri Koyuncu Banu, et al. · Journal of Cranio-Maxillofacial Surgery · 2022

Included by

Arthrocentesis Plus Injectable Platelet-Rich Fibrin in Patients With Temporomandibular Joint Dysfunction: An Updated Meta-Analysis With Trial Sequential Analysis.

Non-Cochrane · intervention · 2026 · cited as Isik 2022 · Table 3; reference list

Outcome this study informs	Pooled effect	Evidence	Certainty
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.57 [-2.36, -0.78]	7 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.68 [-2.46, -0.91]	7 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.86 [-2.35, -1.37]	7 studies	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 5.39 [3.29, 7.5]	6 studies	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 5.03 [2.99, 7.07]	7 studies · 270 participants	Moderate
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Not specified	MD -1.61 [-2.26, -0.95]	2 studies · 112 participants	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · 6 months	MD -1.83 [-2.43, -1.24]	2 studies · 70 participants	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	Meta-regression coefficient 0.0232 [-0.2078, 0.2542]	8 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Not specified	MD -1.59 [-1.88, -1.3]	2 studies · 112 participants	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.64 [-2.41, -0.86]	7 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.62 [-2.28, -0.96]	8 studies · 298 participants	Moderate
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.55 [-2.33, -0.77]	7 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.73 [-2.41, -1.05]	7 studies	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 5.12 [2.87, 7.37]	6 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · 9-12 months	MD -1.13 [-2.13, -0.12]	3 studies · 140 participants	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 3.94 [3.14, 4.73]	6 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Not specified	MD -1.66 [-2.18, -1.14]	2 studies · 112 participants	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 4.85 [2.33, 7.38]	6 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.5 [-2.18, -0.81]	7 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · 3 months	MD -2.13 [-3.75, -0.51]	3 studies · 88 participants	GRADE not reported
Contralateral excursion, change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 0.94 [0.41, 1.48]	3 studies · 144 participants	Moderate
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 4.99 [2.5, 7.48]	6 studies	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 5.51 [3.06, 7.96]	6 studies	GRADE not reported
Maximum mouth opening (MMO), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 5.31 [2.66, 7.96]	6 studies	GRADE not reported
Protrusive movement, change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD 1.08 [0.48, 1.69]	3 studies · 144 participants	Moderate
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Follow-up 3 to 12 months	MD -1.44 [-2.06, -0.81]	7 studies	GRADE not reported
Pain (VAS), change from baseline Arthrocentesis plus injectable platelet-rich fibrin (i-PRF) vs Control interventions (mainly arthrocentesis alone) · Not specified	MD -1.49 [-1.99, -0.99]	2 studies · 112 participants	GRADE not reported

Efficacy of combined therapies on degenerative joint disease of the temporomandibular joint: A systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Işık 2022 · Supplement mmc1 Appendix C section A (RCTs in meta-analysis), A8

The review does not say which of its outcomes this study informs.

2 including reviews in total.