Primary study · included by 1 review

Rofecoxib 50 mg and valdecoxib 20 or 40 mg in adults and adolescents with postoperative pain after third molar extraction: Results of two randomized, double-blind, placebo-controlled, single-dose studies

Daniels 2006 · DANIELS S, DESJARDINS P, BIRD S, et al. · Clinical Therapeutics · 2006

Included by

Cyclooxygenase-2 selective inhibitors increase the risk of alveolar osteitis: A systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Daniels 2006 · Reference [44]; Figures 1-2
Outcome this study informsPooled effectEvidenceCertainty
Alveolar osteitis (dry socket) occurrence
Rofecoxib vs Placebo or untreated control
OR 1.83 [1.05, 3.18]4 studies · 752 participantsGRADE not reported
Alveolar osteitis (dry socket) occurrence
Rofecoxib vs Placebo or untreated control
OR 1.59 [0.92, 2.77]4 studies · 824 participantsGRADE not reported
Alveolar osteitis (dry socket) occurrence
Rofecoxib vs Placebo or untreated control
OR 2.00 [1.18, 3.41]4 studies · 763 participantsGRADE not reported
Alveolar osteitis (dry socket) occurrence
Rofecoxib vs Placebo or untreated control
OR 1.89 [1.15, 3.10]5 studies · 947 participantsGRADE not reported
Alveolar osteitis (dry socket) occurrence
Rofecoxib vs Placebo or untreated control
OR 2.22 [1.21, 4.07]4 studies · 623 participantsGRADE not reported
Alveolar osteitis (dry socket) occurrence
Valdecoxib vs Placebo or untreated control
OR 1.21 [0.60, 2.47]2 studies · 445 participantsGRADE not reported
Alveolar osteitis (dry socket)
COX-2 selective inhibitors, all drugs combined vs Placebo or untreated control
Overall results showed no statistical difference (no overall estimate reported)13 studies · 3820 participantsGRADE not reported
Alveolar osteitis (dry socket) occurrence
Rofecoxib vs Placebo or untreated control
OR 1.89 [1.11, 3.24]4 studies · 826 participantsGRADE not reported

1 including review in total.