evidencegaps
Primary study · included by 1 review

Composition, cross-linking and thermal stability of bone and skin collagens in patients with osteogenesis imperfecta

Herbage 1982 · Herbage D., Borsali F., Buffevant Ch., et al. · Metabolic Bone Disease and Related Research · 1982

Included by

Post-translational modifications of collagen type I in osteogenesis imperfecta: Systematic review and meta-analysis.
Non-Cochrane · other · 2026 · cited as Herbage 1982 · Table 3; Supplementary material 2 (meta-analysis reference list)
Outcome this study informsPooled effectEvidenceCertainty
Ratio of hydroxylysine to hydroxyproline (HYL/HYP) in collagen-I
OI collagen-I (patient-derived bone, fibroblast or dentine samples) vs Control (healthy) collagen-I
Normalized mean difference 0.22 [0.19, 0.25]10 studies · 96 participantsGRADE not reported
Hydroxylysine (HYL) percentage in collagen-I
OI collagen-I (patient-derived bone, fibroblast or dentine samples) vs Control (healthy) collagen-I
Normalized mean difference 0.09 [-0.01, 0.19]3 studies · 62 participantsGRADE not reported
Hydroxylysine (HYL) percentage in collagen-I
OI collagen-I (patient-derived bone, fibroblast or dentine samples) vs Control (healthy) collagen-I
Normalized mean difference 0.33 [0.21, 0.45]20 studies · 150 participantsGRADE not reported
Hydroxylysine (HYL) percentage in collagen-I
OI collagen-I (patient-derived bone, fibroblast or dentine samples) vs Control (healthy) collagen-I
Normalized mean difference 0.37 [0.26, 0.49]17 studies · 88 participantsGRADE not reported

1 including review in total.