evidencegaps
Primary study · included by 1 review

Defective collagen fibril formation and mineralization in osteogenesis imperfecta with congenital joint contractures (Bruck syndrome)

Brenner 1993 · Brenner R. E., Vetter U., Stöss H., et al. · European Journal of Pediatrics · 1993

Included by

Post-translational modifications of collagen type I in osteogenesis imperfecta: Systematic review and meta-analysis.
Non-Cochrane · other · 2026 · cited as Brenner 1993 · Table 3; Supplementary material 2 (meta-analysis reference list)
Outcome this study informsPooled effectEvidenceCertainty
Ratio of hydroxylysine to hydroxyproline (HYL/HYP) in collagen-I
OI collagen-I (patient-derived bone, fibroblast or dentine samples) vs Control (healthy) collagen-I
Normalized mean difference 0.22 [0.19, 0.25]10 studies · 96 participantsGRADE not reported

1 including review in total.