Non-Cochrane · intervention · PM42694976
Efficacy of advanced treatment modalities of dentin hypersensitivity: A systematic review and meta-analysis.
Saxena Vrinda, Shoukath Saina, Saxena Payal, et al. · Journal of oral biology and craniofacial research · 2026 · PubMed · doi:10.1016/j.jobcr.2026.101500
Findings
17 findings
| Population | ||||
|---|---|---|---|---|
| Adults with dentin hypersensitivity | Advanced treatment modalities | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores | SMD -0.99 [-1.28, -0.71] GRADE not reported 2888 participants |
| Adults with dentin hypersensitivity | Advanced treatment modalities | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores | SMD -1.02 [-1.32, -0.73] GRADE not reported 25 studies · 2721 participants |
| Adults with dentin hypersensitivity | Iontophoresis | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Iontophoresis | SMD -1.25 [-1.92, -0.57] GRADE not reported 2 studies |
| Adults with dentin hypersensitivity | Laser therapy | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Laser therapy | SMD -1.66 [-2.73, -0.59] GRADE not reported 264 participants |
| Adults with dentin hypersensitivity | Laser therapy | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Laser therapy | SMD -2.11 [-2.96, -1.26] GRADE not reported 16 studies |
| Adults with dentin hypersensitivity | Calcium phosphate-based agents | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Calcium phosphate-based agents | SMD -0.72 [-1.09, -0.34] GRADE not reported 3 studies |
| Adults with dentin hypersensitivity | Calcium phosphate-based agents | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Calcium phosphate-based agents | SMD -0.54 [-0.91, -0.16] GRADE not reported 429 participants |
| Adults with dentin hypersensitivity | Oxalate-based agents | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Oxalate-based agents | SMD -0.40 [-0.92, 0.12] GRADE not reported 3 studies |
| Adults with clinically diagnosed dentin hypersensitivity of permanent teeth | Arginine-based formulations | Placebo, sham, no treatment or conventional desensitizing agents | Dentin hypersensitivity reduction (VAS, Schiff or verbal rating scores) Follow-up of at least 1 month; time points not separated · Dental clinics · Subgroup 1.1.8 Arginine, Figure 3 | SMD -0.98 [-1.57, -0.39] GRADE not reported 1 study · 50 participants |
| Adults with dentin hypersensitivity | Arginine-calcium carbonate formulations | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Arginine-calcium carbonate formulations | SMD -1.04 [-1.37, -0.72] GRADE not reported 2 studies |
| Adults with dentin hypersensitivity | Bioactive glass | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Bioactive glass | SMD -1.08 [-2.08, -0.09] GRADE not reported 2 studies · 233 participants |
| Adults with dentin hypersensitivity | Nanoparticle-based agents | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Nanoparticle-based agents | SMD -0.87 [-1.50, -0.25] GRADE not reported 3 studies |
| Adults with dentin hypersensitivity | Resin and varnish systems | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Resin and varnish systems | SMD 0.14 [-0.40, 0.68] GRADE not reported 129 participants |
| Adults with dentin hypersensitivity | Resin and varnish systems | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Resin and varnish systems | SMD 0.50 [-0.22, 1.23] GRADE not reported 4 studies |
| Adults with dentin hypersensitivity | Fluoride gel | Conventional or placebo controls; varied by trial | Dentin hypersensitivity pain scores Fluoride gel | SMD -1.16 [-1.56, -0.76] GRADE not reported 1783 participants |
| Adults with clinically diagnosed dentin hypersensitivity of permanent teeth | Potassium salt (subgroup 1.1.3 in Figure 3) | Placebo, sham, no treatment or conventional desensitizing agents | Dentin hypersensitivity reduction (VAS, Schiff or verbal rating scores) Follow-up of at least 1 month; time points not separated · Dental clinics · Subgroup 1.1.3 Potasium salt, Figure 3: not estimable | Not estimable; no data (0 participants) No studies found 0 studies |
| Adults with clinically diagnosed dentin hypersensitivity of permanent teeth | Platelet-rich fibrin | Placebo, sham, no treatment or conventional desensitizing agents | Dentin hypersensitivity reduction (VAS, Schiff or verbal rating scores) Follow-up of at least 1 month; time points not separated · Dental clinics · Planned during protocol development | No studies satisfied the predefined eligibility criteria for PRF No studies found 0 studies |
Included primary studies 48
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Jalaluddin et al. 2019 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| AlQahtani 2023 Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study. PMID:37367153 | 2023 | this review only | not stated | not extracted yet |
| AlQahtani et al. 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Arshad 2021 Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a… PMID:34615511 | 2021 | this review only | not stated | not extracted yet |
| Arshad et al. 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bahal 2019 A randomised controlled trial to investigate the efficacy of an oxalate strip for the management of dentine hypersensitivity pain. PMID:31150729 | 2019 | this review only | not stated | not extracted yet |
| Bahal et al. 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Barros 2022 Effect of 1.5% potassium oxalate on sensitivity control, color change, and quality of life after at-home tooth whitening: A randomized,… PMID:36395262 | 2022 | this review only | not stated | not extracted yet |
| Barros et al. 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Corral 2016 Effect of Oxalic Acid-Based Desensitizing Agent on Cervical Restorations on Hypersensitive Teeth: A Triple-Blind Randomized Controlled… PMID:27792801 | 2016 | this review only | not stated | not extracted yet |
| Corral et al. 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Das 2023 Effect of Iontophoresis on the Effectiveness of Nano-Hydroxyapatite and Pro-argin in In-Office Treatment of Dentin Hypersensitivity: A… PMID:38259360 | 2023 | this review only | not stated | not extracted yet |
| Ding 2020 Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a… PMID:32532267 | 2020 | this review only | not stated | not extracted yet |
| Ding et al. 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Guney 2011 (Table 1 cites reference 25, Yilmaz 2011) Clinical evaluation of Er,Cr:YSGG and GaAlAs laser therapy for treating dentine hypersensitivity: A randomized controlled clinical trial. PMID:21238531 | 2011 | this review only | not stated | not extracted yet |
| Guney et al. 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hasan 2011 (Table 1 reference 27) Long-term effect of diode laser irradiation compared to sodium fluoride varnish in the treatment of dentine hypersensitivity in… PMID:21668343 | 2011 | this review only | not stated | not extracted yet |
| Hasan et al. 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hatem 2021 (Table 1 reference 26) A randomized clinical trial of dentin hypersensitivity reduction over one month after a single topical application of comparable materials. PMID:33762645 | 2021 | this review only | not stated | not extracted yet |
| Hatem et al. 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ivette 2019 Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental… PMID:31790452 | 2019 | this review only | not stated | not extracted yet |
| Ivette et al. 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jalaluddin 2019 Evaluation of the Efficacy of Three Different Treatment Modalities in the Management of Dentinal Hypersensitivity: A Comparative Study DOI:10.5005/jp-journals-10015-1626 | 2019 | this review only | not stated | not extracted yet |
| Matsuura 2022 The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield for cervical dentin hypersensitivity: a pilot randomized controlled… PMID:35843957 | 2022 | this review only | not stated | not extracted yet |
| Matsuura et al. 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Miron 2020 Using Laser-Doppler Flowmetry to Evaluate the Therapeutic Response in Dentin Hypersensitivity. PMID:33256192 | 2020 | this review only | not stated | not extracted yet |
| Miron et al. 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Naghsh 2024 Evaluation of the effects of 980 and 810-nm high-level diode lasers in treating dentin hypersensitivity: A double-blinded randomized… PMID:36605144 | 2022 | this review only | not stated | not extracted yet |
| Naghsh et al. 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Narges 2020 Evaluation of the Effects of 660-nm and 810-nm Low-Level Diode Lasers on the Treatment of Dentin Hypersensitivity. PMID:32273952 | 2020 | this review only | not stated | not extracted yet |
| Narges et al. 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Neuhaus 2013 Effectiveness of a calcium sodium phosphosilicate-containing prophylaxis paste in reducing dentine hypersensitivity immediately and 4… PMID:23414245 | 2013 | this review only | not stated | not extracted yet |
| Neuhaus et al. 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Patil 2015 Evaluation of three different agents for in-office treatment of dentinal hypersensitivity: a controlled clinical study. PMID:25961613 | 2015 | this review only | not stated | not extracted yet |
| Patil et al. 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pepelassi 2012 Effectiveness of an in-office arginine-calcium carbonate paste on dentine hypersensitivity in periodontitis patients: a double-blind,… PMID:25269991 | 2015 | this review only | not stated | not extracted yet |
| Pepelassi et al. 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Seong 2020 A randomised controlled trial investigating efficacy of a novel toothpaste containing calcium silicate and sodium phosphate in dentine… PMID:32497553 | 2020 | this review only | not stated | not extracted yet |
| Seong et al. 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sharma 2013 Randomised clinical efficacy trial of potassium oxalate mouthrinse in relieving dentinal sensitivity. PMID:23929644 | 2013 | this review only | not stated | not extracted yet |
| Sharma et al. 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tevatia 2017 Comparative clinical evaluation of gallium-aluminum-arsenide diode laser and potassium nitrate in treating dentinal hypersensitivity. PMID:29491586 | 2017 | this review only | not stated | not extracted yet |
| Tevatia et al. 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vano 2014 Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: a double-blind randomized controlled trial. PMID:25019114 | 2014 | this review only | not stated | not extracted yet |
| Vano et al. 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yilmaz et al. 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Young Lee 2015 Desensitizing efficacy of nano-carbonate apatite dentifrice and Er,Cr:YSGG laser: a randomized clinical trial. PMID:25594768 | 2015 | this review only | not stated | not extracted yet |
| Young Lee et al. 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Effect of curcumin compared to chlorhexidine on clinical variables of periodontal health: A systematic review and meta-analysis of… (2026) | 1 | 0.01 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older) with clinically diagnosed dentin hypersensitivity of permanent teeth | Adults with dentin hypersensitivity (n=2721 in meta-analysis) |
| Intervention | Advanced modalities: laser therapy, photobiomodulation, bioactive glass, nano-hydroxyapatite, CPP-ACP, iontophoresis, oxalate, arginine, resin and varnish systems, combination therapies | Laser (n=16 studies), resin and varnish (n=4), calcium phosphate (n=3), oxalate (n=3), nanoparticle (n=3), iontophoresis (n=2), arginine (n=2), bioactive glass (n=2) |
| Comparison | Placebo, sham, no treatment or conventional desensitizing agents | Placebo, sham, no treatment or conventional agents |
| Outcomes | Reduction in hypersensitivity on validated scales (VAS, Schiff), duration of relief, adverse effects | Hypersensitivity score reduction (VAS, Schiff, VRS), SMD |
| Study designs | Randomized controlled trials | RCTs (n=31; 25 in meta-analysis) |
| Timing | At least 1 month follow-up | Follow-up from immediate to 6 months or longer |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Yes | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Yes | no |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes | NRSI: N/A · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: No | NRSI: N/A · RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |