Non-Cochrane · prognostic · PM42687938
MRI features of parenchymal neuro-Behçet's disease: a systematic review and meta-analysis.
Alnajashi Hind, Almohammed Hussain Ali J, Morad Ahmed Salah, et al. · Frontiers in neurology · 2026 · PubMed · doi:10.3389/fneur.2026.1818678
Findings
Population Adults with parenchymal neuro-Behçet’s disease
10 findings
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Contrast-enhancing lesions | OR 2.58 [1.04, 6.40] GRADE not reported 2 studies · 104 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Basal ganglia lesions | OR 1.86 [0.77, 4.44] GRADE not reported 2 studies · 137 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Brainstem atrophy | OR 0.03 [0.01, 0.11] GRADE not reported 2 studies · 104 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Spinal cord lesions | OR 1.64 [0.44, 6.09] GRADE not reported 2 studies · 137 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Thalamic lesions | OR 1.93 [0.69, 5.42] GRADE not reported 2 studies · 137 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | White matter lesions | OR 0.92 [0.45, 1.89] GRADE not reported 3 studies · 180 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Cerebellar lesions | OR 1.11 [0.27, 4.50] GRADE not reported 2 studies · 137 participants |
| Acute parenchymal NBD | Chronic progressive parenchymal NBD | Brainstem lesions | OR 1.19 [0.66, 2.15] GRADE not reported 3 studies · 241 participants |
| Mild-to-moderate NBD (mRS 0–3) | Severe NBD (mRS 4–6) | Thalamic lesions | OR 0.31 [0.07, 1.36] GRADE not reported 2 studies · 87 participants |
| Mild-to-moderate NBD (mRS 0–3) | Severe NBD (mRS 4–6) | Brainstem lesions | OR 0.42 [0.10, 1.68] GRADE not reported 2 studies · 87 participants |
Included primary studies 8
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Chamoun 2025 Clinical Characteristics, MRI Findings, Disease Progression, and Management of Neuro-Behçet's Disease: A Retrospective Study in Lebanon. PMID:40283375 | 2025 | this review only | not stated | not extracted yet |
| Demir 2003 Cranial MRI in Beh�et?s disease: 134�examinations of 98�patients DOI:10.1007/s00234-003-1102-1 | 2003 | this review only | not stated | not extracted yet |
| Demir 2003 Cranial MRI in Behçet's disease: 134 examinations of 98 patients. PMID:14557904 | 2003 | this review only | not stated | not extracted yet |
| Haghighi 2010 MRI findings of neuro-Behcet's disease. PMID:21165752 | 2011 | this review only | not stated | not extracted yet |
| Ideguchi 2010 Neurological manifestations of Behçet's disease in Japan: a study of 54 patients. PMID:20127350 | 2010 | this review only | not stated | not extracted yet |
| Kim 2019 Clinical and Radiographic Characteristics of Neuro-Behçet's Disease in South Korea. PMID:31591829 | 2019 | this review only | not stated | not extracted yet |
| Noel 2014 Long-term outcome of neuro-Behçet's disease. PMID:24782188 | 2014 | this review only | not stated | not extracted yet |
| Sorgun 2018 Clinical characteristics and prognosis of Neuro-Behçet's disease. PMID:30308139 | 2018 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (>=18 years) with confirmed neuro-Behcet's disease (ISG-BD criteria), parenchymal NBD | Adults with parenchymal NBD (n=327; 161 acute, 67 chronic progressive, 98 unclassified) |
| Intervention | Acute parenchymal NBD; mild-to-moderate NBD (mRS 0-3) | Acute NBD; mild-to-moderate NBD |
| Comparison | Chronic progressive parenchymal NBD; severe NBD (mRS 4-6) | Chronic progressive NBD; severe NBD |
| Outcomes | MRI lesion location (brainstem, white matter, basal ganglia, cerebellum, spinal cord, thalamus), MRI characteristics; secondary: resolution of brain lesions on follow-up MRI | Lesion site (6 sites), brainstem atrophy, enhancing lesion; brainstem and thalamic lesions by severity; lesion resolution not pooled |
| Study designs | Retrospective studies only | 7 retrospective cohort studies (n=7) |
| Timing | Not specified | Not specified |