Non-Cochrane · intervention · PM42615684
Comparative efficacy of violet light, bleaching gel, or their combination, in in-office bleaching: a systematic review and network meta-analysis.
Favoreto Michael Willian, Terra Renata Maria Oleniki, Camargo Camila Mendes, et al. · Brazilian oral research · 2026 · PubMed · doi:10.1590/1807-3107bor-2026.vol40.056
Findings
Population Adults with permanent dentition undergoing in-office tooth bleaching
82 findings
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Sensitivity NMA excluding studies with imputed data | MD 2.93 [0.803, 5.08] GRADE not reported Studies not reported |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -0.772 [-3.12, 1.52] GRADE not reported 5 studies · 360 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -0.69 [-1.86, 0.47] GRADE not reported 4 studies · 190 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD 2.36 [-0.736, 5.34] GRADE not reported 6 studies · 360 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD 3.13 [1.33, 4.97] Moderate Downgraded: imprecision 11 studies · 506 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | RR 1.07 [0.73, 1.56] GRADE not reported 4 studies · 198 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), all studies | RR 1.03 [0.648, 1.79] 20 [-168, 380] per 1000 Very low Downgraded: risk of bias, imprecision, inconsistency 12 studies · 682 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -0.73 [-2.06, 0.59] GRADE not reported 5 studies · 212 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD 2.92 [1.85, 3.98] Moderate Downgraded: imprecision 9 studies · 344 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Sensitivity NMA excluding Costa 2018 | MD -0.188 [-1.71, 1.38] GRADE not reported Studies not reported |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD 0.165 [-1.51, 1.94] GRADE not reported 5 studies · 300 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -0.16 [-0.77, 0.46] Very low Downgraded: risk of bias, inconsistency 9 studies · 410 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | RR 1.03 [0.79, 1.34] 15 [-104, 168] per 1000 Very low Downgraded: risk of bias, imprecision, inconsistency 11 studies · 489 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -0.241 [-1.93, 1.42] Very low Downgraded: risk of bias, inconsistency 10 studies · 576 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD 0.853 [-0.845, 2.59] Very low Downgraded: risk of bias, imprecision, inconsistency 10 studies · 622 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD 2.62 [0.74, 4.50] GRADE not reported 4 studies · 198 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | RR 1.04 [0.68, 1.60] GRADE not reported 7 studies · 291 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | RR 0.954 [0.406, 2.14] GRADE not reported 5 studies · 300 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD 0.28 [-0.30, 0.86] GRADE not reported 4 studies · 198 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD 3.66 [1.84, 5.48] GRADE not reported 4 studies · 106 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Sensitivity NMA excluding studies with imputed data | MD 0.707 [-1.14, 2.56] GRADE not reported Studies not reported |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD 2.37 [0.79, 3.95] GRADE not reported 5 studies · 238 participants |
| Bleaching gel combined with violet light (BGVIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD 0.86 [-0.63, 2.35] Very low Downgraded: risk of bias, imprecision, inconsistency 8 studies · 388 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -1.95 [-3.59, -0.30] GRADE not reported 3 studies · 159 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Sensitivity NMA excluding studies with imputed data | MD -3.56 [-5.62, -1.38] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Sensitivity NMA excluding studies with imputed data | MD -3.79 [-5.81, -1.85] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -4.93 [-7.57, -2.29] GRADE not reported 4 studies · 170 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | RR 0.520 [0.200, 1.19] GRADE not reported 5 studies · 300 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -3.37 [-5.19, -1.58] Moderate Downgraded: imprecision 10 studies · 622 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | RR 0.18 [0.11, 0.30] GRADE not reported 4 studies · 155 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | RR 0.27 [0.10, 0.70] -480 [-592, -197] per 1000 Very low Downgraded: risk of bias, inconsistency 8 studies · 325 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -2.87 [-4.83, -0.964] Low Downgraded: risk of bias, imprecision 10 studies · 576 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -2.81 [-5.70, 0.08] Low Downgraded: risk of bias, imprecision 6 studies · 269 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), all studies | RR 0.342 [0.164, 0.632] -326 [-415, -183] per 1000 Very low Downgraded: risk of bias, inconsistency 12 studies · 682 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -3.68 [-5.36, -2.00] High 7 studies · 329 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -1.91 [-4.27, 0.44] GRADE not reported 3 studies · 66 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -3.77 [-6.87, -0.68] GRADE not reported 5 studies · 210 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Sensitivity NMA excluding Costa 2018 | MD -2.11 [-3.98, -0.254] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -3.02 [-4.84, -1.11] Moderate Downgraded: imprecision 11 studies · 506 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -1.30 [-2.55, -0.06] GRADE not reported 4 studies · 170 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -5.68 [-6.68, -4.68] GRADE not reported 2 studies · 99 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -1.22 [-3.06, 0.310] GRADE not reported 5 studies · 300 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -3.75 [-6.69, -0.852] GRADE not reported 6 studies · 360 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | RR 0.38 [0.09, 1.51] GRADE not reported 4 studies · 170 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -4.64 [-7.11, -2.40] GRADE not reported 5 studies · 360 participants |
| Violet light alone (VIOL) | Bleaching gel alone (BG) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -2.97 [-4.90, -1.05] Moderate Downgraded: imprecision 8 studies · 276 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), all studies | RR 0.331 [0.151, 0.620] -326 [-423, -183] per 1000 Moderate Downgraded: risk of bias 12 studies · 682 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct estimate (node-split, Bayesian), excluding high risk of bias studies | RR 0.637 [0.191, 1.74] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | RR 0.55 [0.16, 1.84] GRADE not reported 3 studies · 130 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct estimate (node-split, Bayesian), excluding high risk of bias studies | MD -1.49 [-4.45, 1.09] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct estimate (node-split, Bayesian), all studies | MD -2.98 [-6.46, -0.400] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -3.75 [-7.61, 0.11] GRADE not reported 2 studies · 96 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Indirect estimate (node-split), excluding high risk of bias studies | MD -5.58 [-15.3, 4.17] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Indirect estimate (node-split), all studies | MD -5.70 [-10.5, -1.04] Very low Downgraded: imprecision Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Indirect estimate (node-split), all studies | MD -3.77 [-10.6, 3.55] Low Downgraded: imprecision Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct estimate (node-split, Bayesian), excluding high risk of bias studies | MD -3.55 [-7.74, 0.304] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -4.21 [-6.31, -2.23] High 10 studies · 622 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Indirect estimate (node-split), excluding high risk of bias studies | MD -1.18 [-7.76, 5.42] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | RR 0.545 [0.195, 1.36] GRADE not reported 5 studies · 300 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct estimate (node-split, Bayesian), all studies | MD -6.53 [-9.52, -3.53] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Indirect estimate (node-split), excluding high risk of bias studies | MD -4.82 [-21.2, 11.6] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | RR 0.22 [0.11, 0.46] GRADE not reported 4 studies · 150 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -2.53 [-4.63, -0.587] Low Downgraded: risk of bias, imprecision 10 studies · 576 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -2.45 [-3.99, -0.92] Low Downgraded: risk of bias, imprecision 5 studies · 226 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -6.12 [-9.26, -2.95] GRADE not reported 6 studies · 360 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct estimate (node-split, Bayesian), all studies | RR 0.354 [0.111, 0.741] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Indirect estimate (node-split), all studies | MD -1.66 [-8.81, 5.51] Very low Downgraded: imprecision Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -6.19 [-9.99, -2.39] GRADE not reported 4 studies · 170 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Indirect estimate (node-split), excluding high risk of bias studies | RR 0.207 [0.0132, 2.84] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -6.52 [-9.36, -3.69] High 6 studies · 222 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | MD -3.85 [-5.44, -2.26] High 5 studies · 225 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct estimate (node-split, Bayesian), excluding high risk of bias studies | MD -6.22 [-11.7, -0.727] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -7.53 [-9.34, -5.71] GRADE not reported 2 studies · 52 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Instrumental color change (delta E*ab) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), all studies | MD -6.15 [-8.18, -4.09] High 11 studies · 506 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -1.39 [-3.47, 0.288] GRADE not reported 5 studies · 300 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, high risk of bias studies | MD -4.16 [-6.12, -2.21] GRADE not reported 2 studies · 95 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct estimate (node-split, Bayesian), all studies | MD -3.80 [-6.30, -1.42] GRADE not reported Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Network estimate (Bayesian NMA), excluding high risk of bias studies | MD -3.87 [-6.51, -1.40] GRADE not reported 5 studies · 360 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Direct pairwise random-effects meta-analysis, all studies | RR 0.32 [0.11, 0.88] -439 [-575, -77] per 1000 Low Downgraded: risk of bias, imprecision 7 studies · 280 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Risk of spontaneous tooth sensitivity During or soon after bleaching · In-office bleaching · Indirect estimate (node-split), all studies | RR 0.156 [0.0113, 1.41] -427 [-501, 102] per 1000 Very low Downgraded: imprecision Studies not reported |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Visual color change (delta SGU/final SGU) Color change measured as close as possible to 30 days post-bleaching (7 to 30 days) · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -3.69 [-5.88, -1.51] GRADE not reported 3 studies · 130 participants |
| Violet light alone (VIOL) | Bleaching gel combined with violet light (BGVIOL) | Intensity of spontaneous tooth sensitivity (VAS 0-10) Worst value during or soon after bleaching · In-office bleaching · Direct pairwise meta-analysis, some concerns/low risk of bias studies | MD -1.68 [-3.78, 0.41] GRADE not reported 3 studies · 130 participants |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Brugnera 2019 Clinical Evaluation of In-Office Dental Bleaching Using a Violet Light-Emitted Diode. PMID:31436475 | 2020 | this review only | not stated | not extracted yet |
| Castro 2024 Bleaching efficacy of in-office bleaching with violet light using low-concentration hydrogen peroxide nanoparticulate photocatalyst gel: A… PMID:39586392 | 2024 | this review only | not stated | not extracted yet |
| Costa 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ferreira and Catao 2023 Randomized clinical trial comparing the violet light emitting diode system and other tooth whitening techniques. PMID:37743453 | 2023 | this review only | not stated | not extracted yet |
| Kury 2020 Effect of violet LED light on in-office bleaching protocols: a randomized controlled clinical trial. PMID:32428059 | 2020 | this review only | not stated | not extracted yet |
| Kury 2022 (6 and 12 month follow-up of Kury 2020/2021) Colorimetric evaluation after in-office tooth bleaching with violet LED: 6- and 12-month follow-ups of a randomized clinical trial. PMID:34269885 | 2022 | this review only | not stated | not extracted yet |
| Lopes 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lopes 2024 Effectiveness of violet LED with or without a bleaching gel: a 12-month randomized clinical trial. PMID:39917687 | 2024 | this review only | not stated | not extracted yet |
| Martinho 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mayer-Santos 2022 Blinded, parallel and randomized clinical evaluation of in-office dental bleaching with violet LED (405-410nm). PMID:35123016 | 2022 | this review only | not stated | not extracted yet |
| Panhoca 2022 DOI:10.35248/2247-2452.22.21.1002 | NR | this review only | not stated | not extracted yet |
| Rocha 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Santos 2021 Clinical evaluation of in-office tooth whitening with violet LED (405 nm): A double-blind randomized controlled clinical trial. PMID:34116249 | 2021 | this review only | not stated | not extracted yet |
| Sobral 2020 Longitudinal, Randomized, and Parallel Clinical Trial Comparing a Violet Light-Emitting Diodes System and In-Office Dental Bleaching:… PMID:33567218 | 2021 | this review only | not stated | not extracted yet |
| Toffol 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Trevisan 2022 Clinical performance of 6% hydrogen peroxide containing TiO2N nanoparticles activated by LED in varying wavelengths-a randomized clinical… PMID:34778937 | 2022 | this review only | not stated | not extracted yet |
| Zanin 2025 Bleaching efficacy and tooth sensitivity using violet LED - single-blind randomized controlled trial. PMID:40383865 | 2025 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with permanent dentition | Adults aged 18 to 60 years (mean 23); 16 RCTs (17 articles) |
| Intervention | In-office bleaching with violet light alone (VIOL) or with bleaching gel (BGVIOL) | Violet light alone (VIOL); bleaching gel plus violet light (BGVIOL) (n=16 studies) |
| Comparison | Bleaching gel alone (BG) | Bleaching gel alone (BG) |
| Outcomes | Color change (delta E*ab, delta SGU/final SGU); risk and intensity of tooth sensitivity | delta E*ab (n=11 studies, 506 patients); delta SGU/final SGU (n=10, 622); risk of tooth sensitivity (n=12, 682); intensity of tooth sensitivity (n=10, 576) |
| Study designs | RCTs (parallel, split-mouth or crossover) | RCTs (15 parallel, 1 split-mouth) |
| Timing | Not specified | Color change at 7 to 30 days post-bleaching; sensitivity at worst reported time |