Non-Cochrane · DTA · PM42541433
Comparative Diagnostic Performance of Cone Beam Computed Tomography and Dual-Energy X-Ray Absorptiometry for Low Bone Density Assessment. A Systematic Review and Meta-Analysis.
Alrashidi Mohammad, Elbishari Haitham, Aljanahi May, et al. · Clinical and experimental dental research · 2026 · PubMed · doi:10.1002/cre2.70423
Findings
Population Adults (18 years or older) undergoing both CBCT and DEXA for bone mineral density assessment
7 findings
| CBCT (index test) | DEXA (reference standard) | Negative likelihood ratio for low bone mineral density Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Overall | LR- 0.53 GRADE not reported 13 studies |
| CBCT (index test) | DEXA (reference standard) | Sensitivity and specificity by sample size Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Sample size 60 or more vs fewer than 60 | Subgrouping by sample size (60 or more participants) was significantly associated with pooled sensitivity and specificity (p<0.05); estimates not given numerically GRADE not reported 13 studies |
| CBCT (index test) | DEXA (reference standard) | Positive likelihood ratio for low bone mineral density Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Overall | LR+ 3 GRADE not reported 13 studies |
| CBCT (index test) | DEXA (reference standard) | Area under the SROC curve for detecting low bone mineral density Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Overall | AUC 0.73 [0.69, 0.77] GRADE not reported 13 studies |
| CBCT (index test) | DEXA (reference standard) | Pooled sensitivity for detecting low bone mineral density Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Overall | Sensitivity 0.58 [0.50, 0.67] GRADE not reported 13 studies |
| CBCT (index test) | DEXA (reference standard) | Pooled specificity for detecting low bone mineral density Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Overall | Specificity 0.78 [0.69, 0.86] GRADE not reported 13 studies |
| CBCT (index test) | DEXA (reference standard) | Sensitivity and specificity by anatomical site Single time point (cross-sectional) · Dental imaging; mandible, cervical vertebrae and jaw sites · Cervical vertebrae vs other sites | Anatomical site (cervical vertebrae vs other sites) was significantly associated with pooled sensitivity and specificity (p<0.05); estimates not given numerically GRADE not reported 13 studies |
Included primary studies 23
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Barngkgei 2014 Osteoporosis prediction from the mandible using cone-beam computed tomography. PMID:25473633 | 2014 | this review only | not stated | not extracted yet |
| Barngkgei 2015 An innovative approach in osteoporosis opportunistic screening by the dental practitioner: the use of cervical vertebrae and cone beam… DOI:10.1016/j.oooo.2015.08.008 | 2015 | this review only | not stated | not extracted yet |
| Barngkgei 2015 An innovative approach in osteoporosis opportunistic screening by the dental practitioner: the use of cervical vertebrae and cone beam… PMID:26453386 | 2015 | this review only | not stated | not extracted yet |
| Barngkgei 2016 Assessment of jawbone trabecular bone structure amongst osteoporotic women by cone‐beam computed tomography: the OSTEOSYR project DOI:10.1111/jicd.12170 | 2015 | this review only | not stated | not extracted yet |
| Barngkgei 2016 Assessment of jawbone trabecular bone structure amongst osteoporotic women by cone-beam computed tomography: the OSTEOSYR project. PMID:26097193 | 2016 | this review only | not stated | not extracted yet |
| Barra 2021 New mandibular indices in cone beam computed tomography to identify low bone mineral density in postmenopausal women DOI:10.1016/j.oooo.2020.07.016 | 2021 | this review only | not stated | not extracted yet |
| Barra 2021 New mandibular indices in cone beam computed tomography to identify low bone mineral density in postmenopausal women. PMID:32843313 | 2021 | this review only | not stated | not extracted yet |
| Barra 2022 Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users DOI:10.1590/1807-3107bor-2022.vol36.0138 | 2022 | this review only | not stated | not extracted yet |
| Barra 2022 Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users. PMID:36477215 | 2022 | this review only | not stated | not extracted yet |
| Carvalho 2022 Fractal dimension analysis on CBCT scans for detecting low bone mineral density in postmenopausal women. PMID:35387102 | 2022 | this review only | not stated | not extracted yet |
| de Castro 2020 A new cone-beam computed tomography–driven index for osteoporosis prediction DOI:10.1007/s00784-019-03193-4 | 2020 | this review only | not stated | not extracted yet |
| de Castro 2020 A new cone-beam computed tomography-driven index for osteoporosis prediction. PMID:31912243 | 2020 | this review only | not stated | not extracted yet |
| Esmaeli 2017 Efficacy of radiographic density values of the first and second cervical vertebrae recorded by CBCT technique to identify patients with… DOI:10.15171/joddd.2017.034 | 2017 | this review only | not stated | not extracted yet |
| Esmaeli 2017 Efficacy of radiographic density values of the first and second cervical vertebrae recorded by CBCT technique to identify patients with… PMID:29184636 | 2017 | this review only | not stated | not extracted yet |
| Gungor 2016 Evaluation of osteoporosis in jaw bones using cone beam CT and dual-energy X-ray absorptiometry DOI:10.2334/josnusd.15-0609 | 2016 | this review only | not stated | not extracted yet |
| Gungor 2016 Evaluation of osteoporosis in jaw bones using cone beam CT and dual-energy X-ray absorptiometry. PMID:27349539 | 2016 | this review only | not stated | not extracted yet |
| Kato 2019 Digital panoramic radiography and cone-beam CT as ancillary tools to detect low bone mineral density in post-menopausal women DOI:10.1259/dmfr.20180254 | 2019 | this review only | not stated | not extracted yet |
| Kato 2019 Digital panoramic radiography and cone-beam CT as ancillary tools to detect low bone mineral density in post-menopausal women. PMID:30306800 | 2019 | this review only | not stated | not extracted yet |
| Shokri 2019 Relationship of gray values in cone beam computed tomography and bone mineral density obtained by dual energy X-ray absorptiometry DOI:10.1016/j.oooo.2019.04.017 | 2019 | this review only | not stated | not extracted yet |
| Shokri 2019 Relationship of gray values in cone beam computed tomography and bone mineral density obtained by dual energy X-ray absorptiometry. PMID:31171482 | 2019 | this review only | not stated | not extracted yet |
| Slaidina 2022 Gray values of the cervical vertebrae detected by cone beam computed tomography for the identification of osteoporosis and osteopenia in… DOI:10.1016/j.oooo.2021.06.014 | 2022 | this review only | not stated | not extracted yet |
| Slaidina 2022 Gray values of the cervical vertebrae detected by cone beam computed tomography for the identification of osteoporosis and osteopenia in… PMID:34535433 | 2022 | this review only | not stated | not extracted yet |
| Slaidina 2023 The Effect of General Bone Mineral Density on the Quantity and Quality of the Edentulous Mandible: A Cross-Sectional Clinical Study. PMID:36661554 | 2023 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (>=18 years), male and female, undergoing CBCT and DEXA for low BMD assessment | Adults, mostly postmenopausal women (n=13 studies) |
| Intervention | CBCT (index test) | CBCT gray value, radiomorphometric indices, fractal dimension at mandible, jaws and cervical vertebrae (n=13) |
| Comparison | DEXA (reference standard) | DEXA T-score at lumbar spine or femoral neck (n=13) |
| Outcomes | Sensitivity, specificity, PPV, NPV, likelihood ratios, diagnostic odds ratio, AUC | Pooled sensitivity 0.58, specificity 0.78, AUC 0.73, LR+ 3, LR- 0.53 (n=13) |
| Study designs | Prospective or retrospective observational cross-sectional, cohort or case-control studies; English only | Cross-sectional observational studies (n=13) |
| Timing | Not specified | Not specified |