Non-Cochrane · intervention · PM42420435
Should chlorhexidine mouthwash be a concern for blood pressure in dental patients?
Mutahar Mahdi, Alshirah Akram, Al-Moraissi Essam Ahmed · Evidence-based dentistry · 2026 · PubMed · doi:10.1038/s41432-026-01233-z
Findings
Population Predominantly healthy normotensive adults
2 findings
| Chlorhexidine mouthwash (CHX-MW) | Control (comparator not specified in the source) | Systolic blood pressure Intervention duration 3 to 7 days | MD 1.56 [-0.67, 3.80] GRADE not reported Studies not reported |
| Chlorhexidine mouthwash (CHX-MW) | Control (comparator not specified in the source) | Diastolic blood pressure Intervention duration 3 to 7 days | MD -0.10 [-1.99, 1.78] GRADE not reported Studies not reported |
Included primary studies 5
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Bescos 2020 Effects of Chlorhexidine mouthwash on the oral microbiome. PMID:32210245 | 2020 | this review only | not stated | not extracted yet |
| Bescos 2024 The comparative effect of propolis and chlorhexidine mouthwash on oral nitrite-producing bacteria and blood pressure regulation. PMID:39691165 | 2025 | this review only | not stated | not extracted yet |
| Kapil 2013 Physiological role for nitrate-reducing oral bacteria in blood pressure control. PMID:23183324 | 2013 | this review only | not stated | not extracted yet |
| Sundqvist 2016 Effects of antiseptic mouthwash on resting metabolic rate: A randomized, double-blind, crossover study. PMID:27769826 | 2016 | this review only | not stated | not extracted yet |
| Tribble 2019 Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate. PMID:30881924 | 2019 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human populations | Predominantly healthy normotensive adults (n=5 studies) |
| Intervention | Chlorhexidine mouthwash use | Chlorhexidine mouthwash (n=5) |
| Comparison | Not specified | Not specified |
| Outcomes | Changes in systolic and diastolic blood pressure | Systolic and diastolic blood pressure (n=5) |
| Study designs | Randomized, controlled and observational studies | Randomized and non-randomized studies (n=5) |
| Timing | Not specified | Intervention durations 3 to 7 days |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | NR | Yes | no |
| 2Protocol established before the reviewcritical | NR | Partial Yes | no |
| 4Comprehensive literature searchcritical | NR | Partial Yes | no |
| 5Study selection in duplicate | NR | Yes | no |
| Overall | NR | High | no |