Non-Cochrane · prognostic · PM42388444
Safety and feasibility of immediate implant placement in diabetic patients: A systematic review and meta-analysis.
Li Zhangyi, Yu Hengyang, Liang Hong · Biomedical reports · 2026 · PubMed · doi:10.3892/br.2026.2173
Findings
28 findings
| Population | ||||
|---|---|---|---|---|
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) 12 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.06 [-0.03, 0.15] GRADE not reported 5 studies · 589 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing Dental implant treatment, immediate implant placement | MD 0.12 [0.07, 0.17] GRADE not reported 3 studies · 504 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) <=6 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.09 [-0.02, 0.19] GRADE not reported 5 studies · 589 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) Dental implant treatment, immediate implant placement | MD 0.07 [0.02, 0.12] GRADE not reported 6 studies · 2048 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing >=24 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.12 [0.05, 0.19] GRADE not reported 3 studies · 213 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) Dental implant treatment, immediate implant placement | MD 0.17 [-0.02, 0.37] GRADE not reported 4 studies · 594 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) >=24 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.06 [-0.01, 0.14] GRADE not reported 5 studies · 870 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) 12 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.14 [-0.14, 0.42] GRADE not reported 3 studies · 168 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Implant survival rate Dental implant treatment, immediate implant placement · Leave-one-out: Agliardi 2023 excluded | RR 1.01 [0.9, 1.02] GRADE not reported 6 studies |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) <=6 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.14 [-0.11, 0.38] GRADE not reported 3 studies · 213 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing <=6 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.13 [-0.03, 0.29] GRADE not reported 2 studies · 123 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing 12 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.12 [0.02, 0.21] GRADE not reported 3 studies · 168 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Implant survival rate Dental implant treatment, immediate implant placement · Leave-one-out: Aguilar-Salvatierra 2016 excluded | RR 1.0 [0.97, 1.02] GRADE not reported 6 studies |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) >=24 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.23 [-0.15, 0.62] GRADE not reported 3 studies · 213 participants |
| Well-controlled diabetic patients receiving immediate implant placement | Immediate implant placement in well-controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Implant survival rate Dental implant treatment, immediate implant placement | RR 1.0 [0.97, 1.02] GRADE not reported 7 studies · 2246 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing 12 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.21 [0.18, 0.25] GRADE not reported 3 studies · 191 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) Dental implant treatment, immediate implant placement | MD 0.39 [0.25, 0.53] GRADE not reported 4 studies · 522 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Implant survival rate Dental implant treatment, immediate implant placement | RR 0.96 [0.88, 1.06] GRADE not reported 3 studies · 186 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) >=24 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.5 [0.08, 0.91] GRADE not reported 3 studies · 180 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) 12 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.36 [0.08, 0.64] GRADE not reported 3 studies · 159 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) >=24 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.4 [0.06, 0.74] GRADE not reported 3 studies · 202 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Marginal bone loss (mm) <=6 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.42 [0.03, 0.81] GRADE not reported 3 studies · 161 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing >=24 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.24 [0.18, 0.3] GRADE not reported 3 studies · 202 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) Dental implant treatment, immediate implant placement | MD 0.62 [0.38, 0.86] GRADE not reported 4 studies · 566 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing Dental implant treatment, immediate implant placement | MD 0.23 [0.21, 0.26] GRADE not reported 3 studies · 509 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Bleeding on probing <=6 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.26 [0.2, 0.32] GRADE not reported 2 studies · 116 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) <=6 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.94 [0.67, 1.21] GRADE not reported 3 studies · 206 participants |
| Poorly controlled diabetic patients receiving immediate implant placement | Immediate implant placement in poorly controlled diabetic patients | Immediate implant placement in healthy (non-diabetic) patients | Probing depth (mm) 12 months · Dental implant treatment, immediate implant placement · By follow-up duration | MD 0.43 [0.06, 0.8] GRADE not reported 3 studies · 180 participants |
Included primary studies 9
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Agliardi 2023 Clinical outcomes of full-arch immediate fixed prostheses supported by two axial and two tilted implants: A retrospective cohort study… PMID:36760035 | 2023 | 1 other review | not stated | not extracted yet |
| Tawil 2008 Conventional and advanced implant treatment in the type II diabetic patient: surgical protocol and long-term clinical results. PMID:18807573 | 2008 | 1 other review | not stated | not extracted yet |
| Aguilar-Salvatierra 2016 Peri-implant evaluation of immediately loaded implants placed in esthetic zone in patients with diabetes mellitus type 2: a two-year study. PMID:25623884 | 2016 | this review only | not stated | not extracted yet |
| Al Amri 2016 Effect of oral hygiene maintenance on HbA1c levels and peri-implant parameters around immediately-loaded dental implants placed in type-2… PMID:26756309 | 2016 | this review only | not stated | not extracted yet |
| Alves 2010 Immediate implants and immediate loading in periodontally compromised patients-a 3-year prospective clinical study. PMID:20814598 | 2010 | this review only | not stated | not extracted yet |
| Bell 2011 The immediate placement of dental implants into extraction sites with periapical lesions: a retrospective chart review. PMID:21496987 | 2011 | this review only | not stated | not extracted yet |
| D'Orto 2022 Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up. PMID:36142007 | 2022 | this review only | not stated | not extracted yet |
| Gómez-Moreno 2015 Peri-implant evaluation in type 2 diabetes mellitus patients: a 3-year study. PMID:24684438 | 2015 | this review only | not stated | not extracted yet |
| Zhao 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Tobacco Smoking and Smoke-Free Products as Risk Factors for Dental Implants: A Systematic Review. (2026) | 2 | 0.04 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Diabetic patients (well- and poorly controlled), aged >=18 years, and healthy patients undergoing immediate implant placement for single or multiple teeth | 1,350 patients with 1,623 implants (n=10 studies); well-controlled diabetes, poorly controlled diabetes and healthy patients |
| Intervention | Immediate implant placement in diabetic patients | Immediate implant placement (single tooth, full arch, all-on-four) in diabetic patients |
| Comparison | Healthy patients receiving the same intervention (immediate implant placement) | Healthy patients with immediate implant placement |
| Outcomes | Implant survival rate, marginal bone loss, probing depth, bleeding on probing, complications | Implant survival rate (n=7 well-controlled; n=3 poorly controlled); marginal bone loss (n=6; n=4); probing depth (n=4; n=4); bleeding on probing (n=3; n=3); complications (n=2, data not shown) |
| Study designs | Studies comparing diabetic with healthy patients undergoing immediate implant placement; case reports, reviews, meta-analyses, animal studies, sample size <10 and incomplete data excluded | 10 observational studies (retrospective and prospective cohorts; 3-144 months follow-up) |
| Timing | Follow-up >=6 months; subgroups <=6 months, 12 months, >=24 months | Follow-up from 3 months to 15 years; pooled subgroups <=6, 12 and >=24 months |