Non-Cochrane · other · PM42367098
Enamel pits and enamel developmental defects in tuberous sclerosis complex: A descriptive synthesis and pooled prevalence analysis.
Nakagawa H · Medicina oral, patologia oral y cirugia bucal · 2026 · PubMed · doi:10.4317/medoral.28247
Findings
Population Patients with tuberous sclerosis complex (TSC)
3 findings
| Tuberous sclerosis complex (no intervention) | None | Prevalence of enamel pits | Prevalence 66 GRADE not reported 7 studies · 217 participants |
| Tuberous sclerosis complex (TSC patients) | Controls without TSC | Enamel pits (odds in TSC versus controls) Common-effect model | OR 53.92 [27.17, 107.01] GRADE not reported 7 studies · 217 TSC; 1044 controls participants |
| Tuberous sclerosis complex (TSC patients) | Controls without TSC | Enamel pits (odds in TSC versus controls) Random-effects model | OR 79.69 [18.45, 344.25] GRADE not reported 7 studies · 217 TSC; 1044 controls participants |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Araujo 2011 Oral and neurocutaneous phenotypes of familial tuberous sclerosis. PMID:21055980 | 2011 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
| Flanagan 1997 Developmental enamel defects in tuberous sclerosis: a clinical genetic marker? PMID:9279754 | 1997 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
| Hoff 1975 Enamel defects associated with tuberous sclerosis. A clinical and scanning-electron-microscope study. PMID:1057151 | 1975 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
| Korporowicz 2020 Oral Findings in Children, Adolescents and Adults with Tuberous Sclerosis Complex. PMID:32644893 | 2020 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
| Lygidakis 1987 Pitted enamel hypoplasia in tuberous sclerosis patients and first-degree relatives. PMID:3677460 | 1987 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
| Mlynarczyk 1991 Enamel pitting. A common sign of tuberous sclerosis. PMID:2039161 | 1991 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
| Sampson 1992 Pitted enamel hypoplasia in tuberous sclerosis. PMID:1516228 | 1992 | this review only | Prevalence of enamel pits; Enamel pits (odds in TSC versus controls) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human patients diagnosed with tuberous sclerosis complex | TSC patients (n=217 in 7 studies) |
| Intervention | Not specified | Not applicable |
| Comparison | Not specified | Controls in some studies (n=1044 in the forest plot) |
| Outcomes | Enamel pits or enamel developmental defects (prevalence or descriptive data) | Enamel pits (n=7 studies); enamel hypoplasia, incisal edge defects, tooth wear described narratively |
| Study designs | Human clinical studies | 7 clinical studies (1975 to 2020) |
| Timing | Not specified | Not specified |