Non-Cochrane · prognostic · PM42287032
Prognostic Value of Bcl-xL in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Leinonen L, Tiikkaja R, Juola M, et al. · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026 · PubMed · doi:10.1111/jop.70155
Findings
3 findings
| Population | ||||
|---|---|---|---|---|
| Patients with head and neck squamous cell carcinoma (maxillary sinus, oropharyngeal and nasopharyngeal) | High tumoral Bcl-xL expression | Low tumoral Bcl-xL expression | Overall survival | HR 1.12 [0.95, 1.32] GRADE not reported 3 studies · 236 participants |
| Patients with oral squamous cell carcinoma | High tumoral Bcl-xL expression | Low tumoral Bcl-xL expression | Lymph node metastasis | RR 0.82 [0.54, 1.24] GRADE not reported 2 studies · 119 participants |
| Patients with oropharyngeal squamous cell carcinoma | High tumoral Bcl-xL expression | Low tumoral Bcl-xL expression | Lymph node metastasis | RR 1.35 [0.80, 2.29] GRADE not reported 2 studies · 403 participants |
Included primary studies 20
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Alam 2021 Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. PMID:34111459 | 2021 | this review only | not stated | not extracted yet |
| Baltaziak 2006 Expression of Bcl-xL, Bax, and p53 in primary tumors and lymph node metastases in oral squamous cell carcinoma. PMID:17384243 | 2006 | this review only | Lymph node metastasis | not extracted yet |
| Bandoh 2002 Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma. PMID:11932899 | 2002 | this review only | Overall survival | not extracted yet |
| Barber 2013 Molecular predictors of locoregional and distant metastases in oropharyngeal squamous cell carcinoma. PMID:24401183 | 2013 | this review only | Lymph node metastasis | not extracted yet |
| Bauer 2007 Targeting apoptosis to overcome cisplatin resistance: a translational study in head and neck cancer. PMID:17848273 | 2007 | this review only | not stated | not extracted yet |
| Bose 2012 Bax expression measured by AQUAnalysis is an independent prognostic marker in oral squamous cell carcinoma. PMID:22852863 | 2012 | this review only | Lymph node metastasis | not extracted yet |
| Bradford 2014 Biomarkers in advanced larynx cancer. PMID:23775802 | 2014 | this review only | not stated | not extracted yet |
| Camisasca 2009 Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell… PMID:18715811 | 2009 | this review only | not stated | not extracted yet |
| Carter 2019 Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. PMID:31801952 | 2019 | this review only | not stated | not extracted yet |
| Chen 2015 Protein marker profiling in different T classification in laryngeal squamous cell carcinoma. PMID:24753215 | 2015 | this review only | not stated | not extracted yet |
| Kumar 2008a Expression of p53 and Bcl-xL as predictive markers for larynx preservation in advanced laryngeal cancer. PMID:18427001 | 2008 | this review only | not stated | not extracted yet |
| Kumar 2008b EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. PMID:18474878 | 2008 | this review only | Overall survival | not extracted yet |
| Mallick 2013 Bcl-xL protein: predictor of complete tumor response in patients with oral cancer treated with curative radiotherapy. PMID:22987535 | 2013 | this review only | not stated | not extracted yet |
| Pena 1999 Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck. PMID:9921989 | 1999 | this review only | not stated | not extracted yet |
| Thai 2025 Characterizing and Targeting of BCL-2 Family Members in Nasopharyngeal Carcinoma. PMID:39474704 | 2025 | this review only | Overall survival | not extracted yet |
| Thanasan 2023 Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma. PMID:38124771 | 2024 | this review only | not stated | not extracted yet |
| Trask 2002 Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ… PMID:12150516 | 2002 | this review only | not stated | not extracted yet |
| Zhang 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zhang 2014 Bcl-xL overexpression and its association with the progress of tongue carcinoma. PMID:25550772 | 2014 | this review only | not stated | not extracted yet |
| Ziai 2019 The association of Bcl-xL and p53 expression with survival outcomes in oropharyngeal cancer. PMID:30614804 | 2019 | this review only | Lymph node metastasis | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human head and neck squamous cell carcinoma tissue | HNSCC (total 1772 tumor samples; laryngeal n=6, oral n=5, oropharyngeal n=3, unspecified HNSCC n=3, oral tongue n=1, maxillary sinus n=1, nasopharyngeal n=1) |
| Intervention | High Bcl-xL gene or protein expression (immunohistochemistry, RNA in situ hybridization or similar) | High Bcl-xL expression (various antibodies and cutoffs; n=20) |
| Comparison | Low Bcl-xL expression | Low Bcl-xL expression |
| Outcomes | OS, DFS, DSS, PFS, RFS, lymph node metastasis | OS (n=12); DFS (n=7); DSS (n=3); RFS (n=2); EFS (n=1); PFS (n=1); lymph node metastasis (n=10 reported results); meta-analysis of OS (3 studies), LNM in OSCC (2 studies), LNM in OPSCC (2 studies) |
| Study designs | Original research studies | Prognostic marker studies (n=20) |
| Timing | Not specified | Not specified |