Non-Cochrane · prognostic · PM42085120
Safety and major adverse events of endobronchial ultrasound performed under conscious sedation: Insights from 3,454 procedures over 14 years and a systematic review of literature.
Ram Babu, Muthu Valliappan, Sehgal Inderpaul S, et al. · Lung India : official organ of Indian Chest Society · 2026 · PubMed · doi:10.4103/lungindia.lungindia_436_25
Findings
Population Patients undergoing EBUS (diagnostic or staging) in studies with at least 1000 procedures
10 findings
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Mediastinal cyst rupture or surgery | Pooled proportion per 10,000 procedures 3.02 [0.82, 6.59] GRADE not reported 3 studies · 13922 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Respiratory failure | Pooled proportion per 10,000 procedures 8.66 [2.58, 18.32] GRADE not reported 3 studies · 12116 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Bleeding | Pooled proportion per 10,000 procedures 26.22 [0.23, 95.05] GRADE not reported 5 studies · 17683 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Pneumothorax | Pooled proportion per 10,000 procedures 5.48 [1.39, 12.27] GRADE not reported 3 studies · 11713 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Any infectious complication | Pooled proportion per 10,000 procedures 32.7 [10.3, 67.7] GRADE not reported 2 studies · 14171 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Death | Pooled proportion per 10,000 procedures 1.52 [0.41, 3.32] GRADE not reported 7 studies · 27560 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Any complication (major or minor) | Pooled proportion per 10,000 procedures 121 [44, 237] GRADE not reported 7 studies · 27560 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Pneumonia | Pooled proportion per 10,000 procedures 11.65 [1.53, 31.22] GRADE not reported 3 studies · 17294 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Mediastinitis | Pooled proportion per 10,000 procedures 9.57 [3.97, 17.59] GRADE not reported 4 studies · 20748 participants |
| Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) | None (single-arm prevalence) | Pericarditis | Pooled proportion per 10,000 procedures 2.67 [0.46, 6.7] GRADE not reported 2 studies · 10468 participants |
Included primary studies 8
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Asano 2013 Complications associated with endobronchial ultrasound-guided transbronchial needle aspiration: a nationwide survey by the Japan Society… DOI:10.1186/1465-9921-14-50 | 2013 | this review only | not stated | not extracted yet |
| Caglayan 2016 Complications of Convex-Probe Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Multi-Center Retrospective Study DOI:10.4187/respcare.03838 | 2015 | this review only | not stated | not extracted yet |
| Eapen 2013 Complications, Consequences, and Practice Patterns of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration DOI:10.1378/chest.12-0350 | 2013 | this review only | not stated | not extracted yet |
| Index study 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Index study 2025 A revolution in Soviet science. PMID:20253454 | 1947 | this review only | not stated | not extracted yet |
| Kang 2021 Infectious complications of EBUS-TBNA: A nested case-control study using 10-year registry data DOI:10.1016/j.lungcan.2021.08.016 | 2021 | this review only | not stated | not extracted yet |
| Kaya 2022 Is endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) reliable and safe procedure in geriatric patients? DOI:10.1007/s40520-021-02012-9 | 2021 | this review only | not stated | not extracted yet |
| Punjabi 2021 Performance monitoring of EBUS for the staging and diagnosis of lung cancer: auditing the Greater Manchester EBUS service against new… DOI:10.1136/bmjresp-2020-000777 | 2021 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients undergoing EBUS (studies with >=1000 procedures) | Patients undergoing diagnostic or staging EBUS (n=27,560) |
| Intervention | EBUS-TBNA | EBUS-TBNA (7 studies) |
| Comparison | Not applicable (prevalence) | Not applicable (prevalence) |
| Outcomes | Complications of EBUS (death, mediastinitis, bleeding, others) | Any complication; death; bleeding; mediastinitis; pneumonia; pericarditis; respiratory failure; pneumothorax; mediastinal cyst rupture or surgery; any infectious complication |
| Study designs | Studies with >=1000 EBUS procedures; excluded reviews, editorials, non-English, case series | Retrospective studies (n=7) |
| Timing | Not specified | Not specified |