Non-Cochrane · intervention · PM41889481
Platelet-rich fibrin as a therapeutic modality for oroantral communication closure: a systematic review and meta-analysis.
Almutiri Manar Kh, Almutairi Nawaf Ahmad, Almutairy Abdurrahman Saud, et al. · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1759248
Findings
Population Patients with oroantral communications or oroantral fistulas
1 finding
| Platelet-rich fibrin (PRF) closure | Alternative therapeutics (buccal advancement flap, oral wound dressing/gauze, 3D printed mesh) | Successful closure of oroantral communication/fistula Follow-up as reported by included studies (closure typically by 3 weeks) · Oral and maxillofacial surgery · Overall | RR 1.00 [0.90, 1.04] GRADE not reported 6 studies · 296 participants |
Included primary studies 30
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Al-Juboori 2018 Treatment of chronic oroantral fistula with platelet-rich fibrin clot and collagen membrane: a case report DOI:10.2147/ccide.s179751 | 2018 | this review only | not stated | not extracted yet |
| Al-Juboori 2018 Treatment of chronic oroantral fistula with platelet-rich fibrin clot and collagen membrane: a case report. PMID:30519116 | 2018 | this review only | not stated | not extracted yet |
| Assad 2017 Closure of Oroantral Communication Using Platelet-rich Fibrin: A Report of Two Cases. PMID:28713748 | 2017 | this review only | not stated | not extracted yet |
| Bilginaylar 2018 The Use of Platelet-Rich Fibrin for Immediate Closure of Acute Oroantral Communications: An Alternative Approach DOI:10.1016/j.joms.2017.07.168 | 2018 | this review only | not stated | not extracted yet |
| Bilginaylar 2018 The Use of Platelet-Rich Fibrin for Immediate Closure of Acute Oroantral Communications: An Alternative Approach. PMID:28859924 | 2018 | this review only | not stated | not extracted yet |
| Bilginaylar 2019 Comparison of the Clinical Outcomes of Buccal Advancement Flap Versus Platelet-Rich Fibrin Application for the Immediate Closure of Acute… DOI:10.1097/scs.0000000000004958 | 2019 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Bilginaylar 2019 Comparison of the Clinical Outcomes of Buccal Advancement Flap Versus Platelet-Rich Fibrin Application for the Immediate Closure of Acute… PMID:30480627 | 2019 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Demetoglu 2018 Closure of Oroantral Communication With Plasma-Rich Fibrin Membrane DOI:10.1097/scs.0000000000004360 | 2018 | this review only | not stated | not extracted yet |
| Demetoglu 2018 Closure of Oroantral Communication With Plasma-Rich Fibrin Membrane. PMID:29485557 | 2018 | this review only | not stated | not extracted yet |
| Elgabarty 2024 Closure of oroantral fistula using platelet rich fibrin with endoscopic middle meatal antrostomy DOI:10.1186/s12903-024-04409-0 | 2024 | this review only | not stated | not extracted yet |
| Elgabarty 2024 Closure of oroantral fistula using platelet rich fibrin with endoscopic middle meatal antrostomy. PMID:38880902 | 2024 | this review only | not stated | not extracted yet |
| ElShourbagy 2015 Oroantral communication repair using bone substitute and platelets rich fibrin DOI:10.1016/j.tdj.2014.12.001 | 2015 | this review only | not stated | not extracted yet |
| Esen 2021 Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap… DOI:10.1007/s12663-019-01278-x | 2019 | this review only | not stated | not extracted yet |
| Esen 2021 Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap… PMID:33584046 | 2021 | this review only | not stated | not extracted yet |
| George 2018 Triple-Layered Closure of an Oroantral Fistula: A Case Report DOI:10.11607/jomi.5725 | 2018 | this review only | not stated | not extracted yet |
| George 2018 Triple-Layered Closure of an Oroantral Fistula: A Case Report. PMID:28518182 | 2018 | this review only | not stated | not extracted yet |
| Hotta 2024 A Case of Simultaneous Sinus Augmentation and Oroantral Fistula Closure for Implant Preparation DOI:10.1563/aaid-joi-d-24-00116 | 2024 | this review only | not stated | not extracted yet |
| Hotta 2024 A Case of Simultaneous Sinus Augmentation and Oroantral Fistula Closure for Implant Preparation. PMID:39360465 | 2024 | this review only | not stated | not extracted yet |
| Hunger 2023 Platelet-rich fibrin vs. buccal advancement flap for closure of oroantral communications: a prospective clinical study DOI:10.1007/s00784-022-04846-7 | 2023 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Hunger 2023 Platelet-rich fibrin vs. buccal advancement flap for closure of oroantral communications: a prospective clinical study. PMID:36607489 | 2023 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Kaba 2023 Is an Attachable Oral Wound Dressing Effective at Closing an Acute Oroantral Communication? DOI:10.1016/j.joms.2023.09.006 | 2023 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Kaba 2023 Is an Attachable Oral Wound Dressing Effective at Closing an Acute Oroantral Communication? PMID:37802130 | 2023 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Kapustecki 2016 Alternative method to treat oroantral communication and fistula with autogenous bone graft and platelet rich fibrin. PMID:27475687 | 2016 | this review only | not stated | not extracted yet |
| Nama 2022 Effect of Surgical Repair of Chronic Oroantral Fistula Using PRF with Tailored 3D Printed Mesh DOI:10.47750/pnr.2022.13.s03.096 | 2022 | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Orabona 2022 DOI:10.23805/jo.2022.14.25 | NR | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Pal 2022 A Double Barrier Technique in Surgical Closure of Oroantral Communication. PMID:36545175 | 2022 | this review only | not stated | not extracted yet |
| Rebic 2023 Histological analysis of bone three months after the treatment of oroantral communication with autologous platelet-rich fibrin - a case… DOI:10.2298/sarh220704043r | 2023 | this review only | not stated | not extracted yet |
| Shukla 2024 matched by author and year (probable) | NR | this review only | Successful closure of oroantral communication/fistula | not extracted yet |
| Yang 2025 Crestal approach for repair of oroantral bone defects and subsequent implant placement DOI:10.1002/cap.10332 | 2025 | this review only | not stated | not extracted yet |
| Yang 2025 Crestal approach for repair of oroantral bone defects and subsequent implant placement. PMID:39949282 | 2026 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Individuals diagnosed with OACs or OAFs irrespective of age, gender or etiology | Patients with OACs/OAFs (n=442 across 19 studies; ages 7 to 77 years) |
| Intervention | PRF as primary treatment or in bi- or tri-laminar techniques for OAC/OAF closure | Autologous PRF clot or membrane, alone or with bone graft, flaps or sinus lift |
| Comparison | Alternative treatment modalities where applicable (e.g., buccal flap, collagen plug, no treatment) | Buccal advancement flap, buccal fat pad, oral wound dressing, 3D printed mesh, corticocancellous bone allograft; seven studies had no comparator |
| Outcomes | Closure success, postoperative morbidity, tissue healing, healing time, complications | Closure rate (pooled: 6 studies, n=296), healing time, complications, pain, analgesic use, bone density |
| Study designs | RCTs, cohort studies, observational studies, comparative studies, case reports, case series, multi-center studies | 6 case reports, 1 case series, 7 prospective cohort, 2 retrospective cohort, 3 RCTs |
| Timing | Not specified | Follow-up from 3 weeks to 6 months in many studies |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | Yes | yes |
| 4Comprehensive literature searchcritical | Partial Yes | No | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Partial Yes | NRSI: Partial Yes · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: No | NRSI: No · RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |