Non-Cochrane · intervention · PM41704433
Effectiveness of hyaluronic acid vs. surgical and non-surgical methods for Papilla Reconstruction: a systematic review.
Jamjoom Amal Ghazi, Bakhshwain Maha Ali · Frontiers in dental medicine · 2026 · PubMed · doi:10.3389/fdmed.2026.1757417
Findings
Population Adults (>=18 years) with interdental papilla deficiency (black triangles)
3 findings
| Injectable hyaluronic acid gel | Saline placebo (the review also pools the albumin-PRF comparator trial here) | Black-triangle surface area (SABT, mm2) 6 months · Papilla level analysis | MD -0.12 [-0.31, 0.08] GRADE not reported 2 studies · 92 participants |
| Injectable hyaluronic acid gel | Saline placebo | Papilla height (mm) Split-mouth trials | MD -0.05 [-0.19, 0.09] GRADE not reported Studies not reported |
| Injectable hyaluronic acid | Surgical papilla reconstruction (connective tissue graft, tunneling, envelope techniques) | Papilla augmentation and black-triangle reduction | no estimate extracted No studies found 0 studies |
Included primary studies 3
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Abdelraouf 2019 Assessment of Hyaluronic Acid Gel Injection in the Reconstruction of Interdental Papilla: A Randomized Clinical Trial. PMID:31316670 | 2019 | this review only | Black-triangle surface area (SABT, mm2) | not extracted yet |
| Ni 2021 Hyaluronic acid vs. physiological saline for enlarging deficient gingival papillae: a randomized controlled clinical trial and an in vitro… PMID:34268372 | 2021 | this review only | Papilla height (mm) | not extracted yet |
| Vadiati Saberi 2024 Comparison of the effect of albumin with platelet-rich fibrin (Alb-PRF) gel and hyaluronic acid gel injection on interdental papilla… PMID:39758262 | 2024 | this review only | Black-triangle surface area (SABT, mm2) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (>=18 years) with clinically evident interdental papilla deficiency or reduced papilla fill without interdental attachment loss | Adults with Nordland and Tarnow Class I/II papilla deficiency (n=8 to 24 patients; 30 to 84 papillae per trial) |
| Intervention | Injectable hyaluronic acid, alone or as an adjunct | Injectable HA gel (Restylane-Lidocaine, Revofil, HyaDENT BG, Qi Sheng) in 2 to 3 sessions (n=3 trials) |
| Comparison | Surgical (connective tissue graft, tunneling, envelope) or non-surgical (collagen matrix, platelet-rich fibrin, no treatment) interventions | Saline placebo (n=2), albumin-PRF or injectable PRF (n=1) |
| Outcomes | Primary: surface area of the black triangle or papilla fill; secondary: esthetic satisfaction, soft-tissue thickness/volume, complications, stability, retreatment | SABT, papilla height, patient satisfaction (VAS), fibroblast proliferation in vitro |
| Study designs | Randomized and split-mouth randomized controlled trials | 3 RCTs (parallel-group and split-mouth) |
| Timing | Not specified | 3 to 12 months follow-up |