Non-Cochrane · aetiology · PM41696934
Human Milk Bioactive Compounds and Allergic- and Infectious-Related Infant Outcomes: A Systematic Review.
Flores Ventura Eduard, Guseva Daria, Hübert Vanessa, et al. · Molecular nutrition & food research · 2026 · PubMed · doi:10.1002/mnfr.70390
Findings
Population Breastfed infants whose mothers provided human milk samples
48 findings
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-6 content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.13 [-0.39, 0.12] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linoleic acid (18:2n-6) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD -0.07 [-0.26, 0.12] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linoleic acid (18:2n-6) content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.12 [-0.38, 0.13] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-6 content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.54 [-1.30, 0.22] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-6 content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD -0.17 [-0.36, 0.02] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-3 content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD 0.10 [-0.09, 0.29] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linoleic acid (18:2n-6) content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD 0.00 [-0.28, 0.28] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-6 content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD -0.30 [-0.82, 0.22] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Ratio n-6:n-3 content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD -0.24 [-0.43, -0.05] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Ratio n-6:n-3 content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.03 [-0.28, 0.23] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Arachidonic acid (20:4n-6) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD -0.18 [-0.37, 0.01] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Dihomo-gamma-linolenic acid (DGLA, 20:3n-6) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.47 [-1.00, 0.06] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Ratio n-6:n-3 content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD 0.85 [-1.34, 3.04] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linolenic acid (18:3n-3) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.56 [-1.79, 0.67] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Eicosapentaenoic acid (EPA, 20:5n-3) content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.03 [-0.29, 0.23] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-3 content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -1.22 [-4.06, 1.62] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Arachidonic acid (20:4n-6) content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.11 [-0.37, 0.14] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-3 content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD 0.23 [-0.05, 0.51] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-3 content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.02 [-0.28, 0.24] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Eicosapentaenoic acid (EPA, 20:5n-3) content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD -0.24 [-0.52, 0.05] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linoleic acid (18:2n-6) content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD -0.02 [-0.34, 0.31] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linolenic acid (18:3n-3) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD 0.05 [-0.14, 0.24] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Eicosapentaenoic acid (EPA, 20:5n-3) content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD 0.00 [-1.10, 1.10] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-6 content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -0.83 [-2.63, 0.97] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Dihomo-gamma-linolenic acid (DGLA, 20:3n-6) content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD -0.39 [-1.22, 0.44] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Dihomo-gamma-linolenic acid (DGLA, 20:3n-6) content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.27 [-0.52, -0.01] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Arachidonic acid (20:4n-6) content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD -0.12 [-0.84, 0.60] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linoleic acid (18:2n-6) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.37 [-1.10, 0.35] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-3 content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.46 [-1.82, 0.90] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-3 content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD 0.23 [-0.05, 0.51] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Ratio n-6:n-3 content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD -0.53 [-0.92, -0.14] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Ratio n-6:n-3 content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD -0.49 [-0.77, -0.21] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linolenic acid (18:3n-3) content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -1.12 [-3.66, 1.43] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Dihomo-gamma-linolenic acid (DGLA, 20:3n-6) content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD -0.22 [-0.50, 0.06] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linoleic acid (18:2n-6) content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -0.75 [-2.41, 0.90] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Total omega-6 content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD -0.22 [-0.50, 0.06] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Eicosapentaenoic acid (EPA, 20:5n-3) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD -0.12 [-0.31, 0.07] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Dihomo-gamma-linolenic acid (DGLA, 20:3n-6) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; common-effect model | SMD -0.24 [-0.43, -0.06] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Dihomo-gamma-linolenic acid (DGLA, 20:3n-6) content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -0.61 [-1.63, 0.41] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linolenic acid (18:3n-3) content, infants with vs without atopic dermatitis Mature milk · Mature milk; common-effect model | SMD -0.06 [-0.32, 0.20] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Arachidonic acid (20:4n-6) content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -0.68 [-2.20, 0.84] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linolenic acid (18:3n-3) content, infants with vs without atopic dermatitis Colostrum · Colostrum; random-effects model | SMD -0.05 [-1.12, 1.03] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Arachidonic acid (20:4n-6) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.36 [-1.06, 0.34] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Eicosapentaenoic acid (EPA, 20:5n-3) content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD -0.54 [-1.86, 0.77] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Eicosapentaenoic acid (EPA, 20:5n-3) content, infants with vs without atopic dermatitis Mature milk · Mature milk; random-effects model | SMD -1.17 [-3.88, 1.54] GRADE not reported 2 studies · 261 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Ratio n-6:n-3 content, infants with vs without atopic dermatitis Colostrum and mature milk · All lactation stages; random-effects model | SMD 0.11 [-1.06, 1.28] GRADE not reported 3 studies · 495 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Linolenic acid (18:3n-3) content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD 0.18 [-0.10, 0.47] GRADE not reported 2 studies · 234 participants |
| Human milk fatty acid concentration (exposure) in infants who developed atopic dermatitis | Human milk fatty acid concentration in infants without atopic dermatitis | Human milk Arachidonic acid (20:4n-6) content, infants with vs without atopic dermatitis Colostrum · Colostrum; common-effect model | SMD -0.26 [-0.54, 0.03] GRADE not reported 2 studies · 234 participants |
Included primary studies 35
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Aparicio 2020 Microbiological and Immunological Markers in Milk and Infant Feces for Common Gastrointestinal Disorders: A Pilot Study. PMID:32121004 | 2020 | this review only | not stated | not extracted yet |
| Berdi 2019 Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood. PMID:30368940 | 2019 | this review only | not stated | not extracted yet |
| Böttcher 2008 Low breast milk TGF-beta2 is induced by Lactobacillus reuteri supplementation and associates with reduced risk of sensitization during… PMID:18221472 | 2008 | this review only | not stated | not extracted yet |
| Chen 2025 Human milk oligosaccharides in Chinese lactating mothers and relationship with allergy development in offspring. PMID:37061931 | 2025 | this review only | not stated | not extracted yet |
| Dai 2023 Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk. PMID:36603585 | 2023 | this review only | not stated | not extracted yet |
| Duchén 2000 Human milk polyunsaturated long-chain fatty acids and secretory immunoglobulin A antibodies and early childhood allergy. PMID:10768733 | 2000 | this review only | not stated | not extracted yet |
| Dzidic 2020 Allergy development is associated with consumption of breastmilk with a reduced microbial richness in the first month of life. PMID:31736150 | 2020 | this review only | not stated | not extracted yet |
| Fang 2024 Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization. PMID:39293435 | 2024 | this review only | not stated | not extracted yet |
| Glass 1983 Protection against cholera in breast-fed children by antibodies in breast milk. PMID:6843632 | 1983 | this review only | not stated | not extracted yet |
| Hogendorf 2013 Is there any association between secretory IgA and lactoferrin concentration in mature human milk and food allergy in breastfed children. PMID:23749695 | 2013 | this review only | not stated | not extracted yet |
| Hoppu 2005 Vitamin C in breast milk may reduce the risk of atopy in the infant. PMID:15340369 | 2005 | this review only | not stated | not extracted yet |
| Hoppu 2005 Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant. PMID:16131990 | 2005 | this review only | not stated | not extracted yet |
| Hua 2019 Association of maternal allergy with human milk soluble CD14 and fatty acids, and early childhood atopic dermatitis. PMID:30561094 | 2019 | this review only | not stated | not extracted yet |
| Järvinen 2014 Role of maternal elimination diets and human milk IgA in the development of cow's milk allergy in the infants. PMID:24164317 | 2014 | this review only | not stated | not extracted yet |
| Jepsen 2016 High breast milk IL-1β level is associated with reduced risk of childhood eczema. PMID:27251401 | 2016 | this review only | not stated | not extracted yet |
| Jêvinen 2000 Does low IgA in human milk predispose the infant to development of cow's milk allergy? PMID:11004235 | 2000 | this review only | not stated | not extracted yet |
| Le Doare 2017 SIgA, TGF-β1, IL-10, and TNFα in Colostrum Are Associated with Infant Group B Streptococcus Colonization. PMID:29109718 | 2017 | this review only | not stated | not extracted yet |
| Lif Holgerson 2023 The breast milk and childhood gastrointestinal microbiotas and disease outcomes: a longitudinal study. PMID:36216869 | 2023 | this review only | not stated | not extracted yet |
| Logan 2017 New approach shows no association between maternal milk fatty acid composition and childhood wheeze or asthma. PMID:28306160 | 2017 | this review only | not stated | not extracted yet |
| Logan 2019 Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies. PMID:30084516 | 2019 | this review only | not stated | not extracted yet |
| Miliku 2021 Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions. PMID:33711184 | 2021 | this review only | not stated | not extracted yet |
| Morrow 2004 Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. PMID:15343178 | 2004 | this review only | not stated | not extracted yet |
| Oddy 2006 Atopy, eczema and breast milk fatty acids in a high-risk cohort of children followed from birth to 5 yr. PMID:16426248 | 2006 | this review only | not stated | not extracted yet |
| Reichardt 2004 Fatty acids in colostrum from mothers of children at high risk of atopy in relation to clinical and laboratory signs of allergy in the… PMID:15005762 | 2004 | this review only | not stated | not extracted yet |
| Rio‐Aige 2022 Galectins-1, -3 and -9 Are Present in Breast Milk and Have a Role in Early Life Development. PMID:36297023 | 2022 | this review only | not stated | not extracted yet |
| Rosenlund 2016 Breastmilk fatty acids in relation to sensitization - the ALADDIN birth cohort. PMID:27043329 | 2016 | this review only | not stated | not extracted yet |
| Seppo 2021 Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle. PMID:33905556 | 2021 | this review only | not stated | not extracted yet |
| Simpson 2015 Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring. PMID:26657066 | 2015 | this review only | not stated | not extracted yet |
| Siziba 2021 Associations of Human Milk Oligosaccharides With Otitis Media and Lower and Upper Respiratory Tract Infections up to 2 Years: The Ulm… PMID:34760912 | 2021 | this review only | not stated | not extracted yet |
| Snijders 2006 Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). PMID:17177685 | 2006 | this review only | not stated | not extracted yet |
| Tellez 2003 Antibodies in mother's milk protect children against giardiasis. PMID:12875519 | 2003 | this review only | not stated | not extracted yet |
| Van Elten 2015 Breast milk fatty acid composition has a long-term effect on the risk of asthma, eczema, and sensitization. PMID:26214160 | 2015 | this review only | not stated | not extracted yet |
| Wachman 2023 Maternal, Infant, and Breast Milk Antibody Response Following COVID-19 Infection in Early Versus Late Gestation. PMID:36729773 | 2023 | this review only | not stated | not extracted yet |
| Wang 2022 Association Between Breastmilk Microbiota and Food Allergy in Infants. PMID:35096637 | 2021 | this review only | not stated | not extracted yet |
| Wu 2021 Breast milk flora plays an important role in infantile eczema: cohort study in Northeast China. PMID:33735474 | 2021 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Healthy mother-infant pairs; children from birth to 18 years (excluding preterm, very low birth weight, diseased-only mothers) | 9,298 mother-infant dyads in 34 studies |
| Intervention | Human milk bioactive compounds and microbiota (exposure), including fatty acids, oligosaccharides, immunoglobulins, cytokines | HM fatty acids (n=23 studies), HMOs (n=12), microbiota (n=14), cytokines (n=13), immunoglobulins |
| Comparison | Children not exclusively breastfed / different levels of HM components | Infants with versus without the outcome; differing HM compound levels |
| Outcomes | Clinically defined allergy-related (food allergy, sensitization, eczema, atopic dermatitis, asthma) and infectious-related infant outcomes | Food allergy (n=15), sensitization (n=8), atopic dermatitis (n=11), eczema, asthma, diarrhoea, respiratory infections, otitis media, dental caries |
| Study designs | Observational longitudinal studies, cross-sectional studies and trials in humans | Mostly longitudinal prospective studies; 3 cross-sectional; 3 RCTs |
| Timing | Follow-up from birth up to 18 years | 6 months to 14 years follow-up |