Non-Cochrane · intervention · PM41641154
Oral health benefits of Heyndrickxia coagulans: a systematic review and meta-analysis of current evidence.
Cirio Silvia, Campus Guglielmo, Salerno Claudia, et al. · Frontiers in oral health · 2025 · PubMed · doi:10.3389/froh.2025.1733955
Findings
Population Children and adults (healthy or at high caries risk)
2 findings
| Heyndrickxia coagulans probiotic (cake or chewable tablet) | Placebo | Salivary Streptococcus mutans level 7 to 14 days of administration · Clinical trials in Iran and India · Overall | MD -0.74 [-1.38, -0.10] GRADE not reported 3 studies |
| Heyndrickxia coagulans probiotic (cake or chewable tablet) | Placebo | Salivary Streptococcus mutans level 7 to 14 days of administration · Clinical trials in Iran and India · Abstract-reported pooled estimate (four studies, differs from Figure 3) | MD -0.99 [-1.60, -0.39] GRADE not reported 4 studies |
Included primary studies 12
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Krupa 2022 Antimicrobial efficacy of Xylitol, Probiotic and Chlorhexidine mouth rinses among children and elderly population at high risk for dental… PMID:35968060 | 2022 | 1 other review | not stated | not extracted yet |
| Jagadeesh 2017 Clinical effect of pro-biotic containing Bacillus coagulans on plaque induced gingivitis : A randomised clinical pilot study DOI:10.1055/s-0040-1708717 | 2017 | this review only | not stated | not extracted yet |
| Jagadeesh 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jindal 2011 A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children DOI:10.1007/bf03262809 | 2011 | this review only | not stated | not extracted yet |
| Jindal 2011 A comparative evaluation of probiotics on salivary mutans streptococci counts in Indian children. PMID:21806906 | 2011 | this review only | not stated | not extracted yet |
| Koopaie 2018 DOI:10.18869/acadpub.jbums.20.9.48 | NR | this review only | Salivary Streptococcus mutans level | not extracted yet |
| Koopaie 2019 Comparison of the effect of regular and probiotic cake (Bacillus coagulans) on salivary pH and Streptococcus mutans count DOI:10.17219/dmp/99757 | 2019 | this review only | Salivary Streptococcus mutans level | not extracted yet |
| Koopaie 2019 Comparison of the effect of regular and probiotic cake (Bacillus coagulans) on salivary pH and Streptococcus mutans count. PMID:30875151 | 2019 | this review only | Salivary Streptococcus mutans level | not extracted yet |
| Mitic 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ratna Sudha 2020 Evaluation of the Effect of Probiotic Bacillus coagulans Unique IS2 on Mutans Streptococci and Lactobacilli Levels in Saliva and Plaque: A… DOI:10.1155/2020/8891708 | 2020 | this review only | Salivary Streptococcus mutans level | not extracted yet |
| Ratna Sudha 2020 Evaluation of the Effect of Probiotic Bacillus coagulans Unique IS2 on Mutans Streptococci and Lactobacilli Levels in Saliva and Plaque: A… PMID:33456469 | 2020 | this review only | Salivary Streptococcus mutans level | not extracted yet |
| Yendluru 2020 Probiotics an adjuvant in the management of recurrent aphthous ulcer: A randomized clinical trial DOI:10.4103/jiaomr.jiaomr_47_20 | 2020 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis. (2024) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children and adults | Healthy children and adults, high caries risk children and elderly, adults with gingivitis, chronic periodontitis or recurrent aphthous stomatitis (n=8 studies; 30 to 183 participants; ages 5 to 73) |
| Intervention | H. coagulans used as probiotic therapy | H. coagulans via chewable tablet, mouthwash, cake or combined with other strains; 7 to 84 days |
| Comparison | Placebo, other probiotic, other therapy or no treatment | Placebo, other probiotic mouthwash, chlorhexidine, xylitol, tetracyclines alone, scaling and root planing alone |
| Outcomes | All outcomes related to oral health (primary: salivary S. mutans) | Salivary and plaque S. mutans and Lactobacillus, salivary pH, GI, PI, BOP, GBI, PD, CAL, GPx, ulcer size, number and pain |
| Study designs | RCTs and non-randomized studies of interventions (including cohort, before-and-after, cross-sectional, case reports, case series, non-clinical studies) | 7 RCTs and 1 NRSI |
| Timing | Not specified | Follow-up 4 days to 12 weeks |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | No | No | yes |
| 7List of excluded studies with reasonscritical | Yes | Yes | yes |
| 8Included studies described in detail | Yes | Partial Yes | no |
| 9Risk of bias assessed satisfactorilycritical | NRSI: Yes · RCT: Yes | RCT: Yes · NRSI: Yes | no |
| 10Funding of included studies reported | Yes | Yes | yes |
| 11Appropriate meta-analysis methodscritical | NRSI: N/A · RCT: No | NRSI: N/A · RCT: No | yes |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |