Non-Cochrane · intervention · PM41552015
Effect of Ginger Extracts in Remineralization of White Spot Lesions: A Systematic Review and Meta-analysis.
Kannan Sangeetha, Thoppe Dhamodharan Yogesh Kumar, Ravichandran Harshini, et al. · International journal of clinical pediatric dentistry · 2025 · PubMed · doi:10.5005/jp-journals-10005-3337
Findings
Population Extracted teeth with white spot lesions (in vitro)
1 finding
| Ginger-containing agent (ginger extract or ginger-containing dentifrice) | Control or other remineralizing agent (Saleh: control; Gomathi: Patanjali Dant Kanti) | Surface microhardness (Vickers) In vitro laboratory | MD 116.71 [-27.41, 260.84] GRADE not reported 2 studies · 64 participants |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Celik 2021 Do Ginger Extract, Natural Honey and Bitter Chocolate Remineralize Enamel Surface as Fluoride Toothpastes? An In-Vitro Study DOI:10.4103/njcp.njcp_683_20 | 2021 | this review only | not stated | not extracted yet |
| Celik 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Eliwa 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gomathi 2023 matched by author and year (probable) | NR | this review only | Surface microhardness (Vickers) | not extracted yet |
| Hossam 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hossam 2022 Refractive index of a tantalum pentoxide film. PMID:20221112 | 1980 | this review only | not stated | not extracted yet |
| Saleh 2022 matched by author and year (probable) | NR | this review only | Surface microhardness (Vickers) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Teeth with white spot lesions (in vitro) | Extracted bovine and human teeth with white spot lesions (n=5 studies) |
| Intervention | Ginger extracts | Ginger extract or ginger-containing toothpaste (Dabur Red) |
| Comparison | Other remineralizing agents | Eggshell, deionized water, rosemary extract, sodium fluoride varnish, Patanjali Dant Kanti |
| Outcomes | Calcium content, surface microhardness, color, fluorescence | Surface microhardness (3 studies), mineral content (1), fluorescence/color (3) |
| Study designs | In vitro studies (published in English, 2000 to August 2024) | Five in vitro randomized studies |
| Timing | Not specified | Not specified |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | No | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: No · NRSI: N/A | NRSI: N/A · RCT: No | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: No · NRSI: N/A | NRSI: N/A · RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | No | yes |
| 14Heterogeneity explained | No | No | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |