Non-Cochrane · aetiology · PM41129372
Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC).
Näsman Tobias, Birgersson Madeleine, Marklund Linda, et al. · International journal of cancer · 2026 · PubMed · doi:10.1002/ijc.70207
Findings
Population Patients with HPV-associated tonsillar squamous cell carcinoma (TSCC)
3 findings
| Tumor origin (anatomical site of origin within the tonsil) | Crypt origin vs surface origin | Odds of cryptal origin Pathology series of HPV-associated TSCC | OR 3.6 [3.2, 4.0] GRADE not reported 4 studies · 396 participants |
| Tumor origin (anatomical site of origin within the tonsil) | Crypt origin vs surface origin | Proportion of tumors with surface origin Pathology series of HPV-associated TSCC | Proportion (%) 14 [10, 17] GRADE not reported 4 studies · 396 participants |
| Tumor origin (anatomical site of origin within the tonsil) | Crypt origin vs surface origin | Proportion of tumors with crypt origin Pathology series of HPV-associated TSCC | Proportion (%) 87 [83, 90] GRADE not reported 4 studies · 396 participants |
Included primary studies 4
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Begum 2005 Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. PMID:16115905 | 2005 | this review only | not stated | not extracted yet |
| Kim 2007 HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. PMID:17205528 | 2007 | this review only | not stated | not extracted yet |
| Morbini 2015 Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection. PMID:25644820 | 2015 | this review only | not stated | not extracted yet |
| Thompson 2020 Oropharyngeal Squamous Cell Carcinoma in 390 Patients: Analysis of Clinical and Histological Criteria Which Significantly Impact Outcome. PMID:31741151 | 2020 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with HPV-associated oropharyngeal/tonsillar squamous cell carcinoma | HPV-associated tonsillar SCC (n=396 cases with extractable origin) |
| Intervention | Tumor origin site (crypt, surface) | Crypt origin (n=343); surface origin (n=53) |
| Comparison | Not specified | Not applicable |
| Outcomes | Tumor origin; presence and localization of dysplasia and tumor center | Proportion cryptal 87% (83-90%); surface 14% (10-17%); OR cryptal 3.6 (3.2-4.0) |
| Study designs | All types of original studies in English, excluding reviews | 4 retrospective cohort studies |
| Timing | Not specified | Not specified |