Non-Cochrane · prognostic · PM41085212
Prevalence and Patterns of Permanent Tooth Agenesis in Patients With Crouzon or Apert Syndrome: A Systematic Review and Meta-Analysis.
Becerril Santos M Cecilia, Ongkosuwito Edwin M, Papadopoulou Alexandra K, et al. · Orthodontics & craniofacial research · 2026 · PubMed · doi:10.1111/ocr.70046
Findings
127 findings
| Population | ||||
|---|---|---|---|---|
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 41 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 46 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 64.0.0.16 (missing teeth 17,45) | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.16.0 (missing teeth 35) | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 2.2.2.0 (missing teeth 12,22,32) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 16 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 0.16.0.0 (missing teeth 25) | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of mandibular second premolar Inverse variance heterogeneity model | Prevalence (%) 17 [9, 27] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of mandibular second premolar | Prevalence (%) 17 [9, 27] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 32 (FDI) | Prevalence (%) 2 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 15 (FDI) | Prevalence (%) 3 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 2.0.16.16 (missing teeth 12,35,45) | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of mandibular central or lateral incisors Inverse variance heterogeneity model | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 44 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of maxillary lateral incisor | Prevalence (%) 18 [5, 36] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 43 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 35 (FDI) | Prevalence (%) 13 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 26 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 45 (FDI) | Prevalence (%) 16 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 14 (FDI) | Prevalence (%) 2 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 37 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 0.2.0.0 (missing teeth 22) | Prevalence (%) 4 [0, 13] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 11 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of maxillary second molar Inverse variance heterogeneity model | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 12 (FDI) | Prevalence (%) 11 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 25 (FDI) | Prevalence (%) 4 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 23 (FDI) | Prevalence (%) 3 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 33 (FDI) | Prevalence (%) 2 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 27 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 31 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of maxillary second premolar | Prevalence (%) 4 [1, 11] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 16.18.0.0 (missing teeth 15,22,25) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of maxillary lateral incisor Inverse variance heterogeneity model | Prevalence (%) 15 [2, 32] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.0.16 (missing teeth 45) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 36 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 17 (FDI) | Prevalence (%) 2 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 34 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 42 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 22 (FDI) | Prevalence (%) 14 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 4.0.0.0 (missing teeth 13) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 6.6.0.4 (missing teeth 13,12,22,23,33) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of mandibular central or lateral incisors | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 21 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of maxillary second premolar Inverse variance heterogeneity model | Prevalence (%) 4 [1, 11] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 47 (FDI) | Prevalence (%) 1 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 8.8.0.0 (missing teeth 14,24) | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 2.2.0.0 (missing teeth 12,22) | Prevalence (%) 4 [0, 11] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 13 (FDI) | Prevalence (%) 3 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Overall permanent tooth agenesis excluding third molars | Prevalence (%) 37 [28, 48] GRADE not reported 6 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of tooth 24 (FDI) | Prevalence (%) 2 GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.16.16 (missing teeth 35,45) | Prevalence (%) 12 [5, 21] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 2.0.0.0 (missing teeth 12) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 0.4.0.0 (missing teeth 23) | Prevalence (%) 2 [0, 6] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Tooth agenesis pattern TAC 16.16.16.16 (missing teeth 15,25,35,45) | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Apert syndrome | Not reported | None | Agenesis of maxillary second molar | Prevalence (%) 2 [0, 7] GRADE not reported 5 studies · 89 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 16.0.0.0 (missing teeth 15) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 64.0.0.0 (missing teeth 17) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 47 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 44 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 41 (FDI) | Prevalence (%) 6 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 17 (FDI) | Prevalence (%) 5 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.1.1.1 (missing teeth 21,31,41) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 12 (FDI) | Prevalence (%) 5 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.16.16 (missing teeth 35,45) | Prevalence (%) 3 [0, 8] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.0.16 (missing teeth 45) | Prevalence (%) 5 [1, 11] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of maxillary second premolar | Prevalence (%) 10 [4, 17] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 64.64.0.0 (missing teeth 17,27) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of mandibular central or lateral incisors Inverse variance heterogeneity model | Prevalence (%) 7 [2, 14] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 16 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 24 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of maxillary second molar | Prevalence (%) 7 [0, 22] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of mandibular second premolar Inverse variance heterogeneity model | Prevalence (%) 15 [8, 24] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 2.0.0.0 (missing teeth 12) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 16.80.16.16 (missing teeth 15,25,27,35,45) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 25 (FDI) | Prevalence (%) 5 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 36 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 32 (FDI) | Prevalence (%) 2 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 16.0.1.1 (missing teeth 15,31,41) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 27 (FDI) | Prevalence (%) 5 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of mandibular second premolar | Prevalence (%) 15 [8, 24] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.32.0.0 (missing teeth 16) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 33 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.2.0.0 (missing teeth 22) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 42 (FDI) | Prevalence (%) 2 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.64.0.0 (missing teeth 27) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.16.0 (missing teeth 35) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Overall permanent tooth agenesis excluding third molars | Prevalence (%) 31 [17, 46] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 16.0.16.16 (missing teeth 15,35,45) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of mandibular central or lateral incisors | Prevalence (%) 7 [2, 14] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 13 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 14 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.2.2 (missing teeth 32,42) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 0.0.17.1 (missing teeth 35,31,41) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 22 (FDI) | Prevalence (%) 2 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 18.16.0.0 (missing teeth 15,12,25) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of maxillary lateral incisor | Prevalence (%) 6 [1, 14] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 15 (FDI) | Prevalence (%) 10 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of maxillary second molar Inverse variance heterogeneity model | Prevalence (%) 5 [0, 20] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 35 (FDI) | Prevalence (%) 10 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 45 (FDI) | Prevalence (%) 12 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 23 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 34 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 31 (FDI) | Prevalence (%) 6 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 37 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 21 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 2.0.16.16 (missing teeth 12,35,45) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 46 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 43 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 11 (FDI) | Prevalence (%) 1 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 80.16.1.1 (missing teeth 17,15,25,31,41) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of maxillary lateral incisor Inverse variance heterogeneity model | Prevalence (%) 5 [1, 13] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of maxillary second premolar Inverse variance heterogeneity model | Prevalence (%) 10 [4, 17] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Agenesis of tooth 26 (FDI) | Prevalence (%) 2 GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon syndrome | Not reported | None | Tooth agenesis pattern TAC 16.0.0.16 (missing teeth 15,45) | Prevalence (%) 2 [0, 6] GRADE not reported 3 studies · 77 participants |
| Patients with Crouzon or Apert syndrome | Crouzon syndrome | Apert syndrome | Permanent tooth agenesis excluding third molars | RR 0.87 [0.54, 1.41] GRADE not reported 3 studies |
| Patients with Apert syndrome | left-sided agenesis | right-sided agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Apert syndrome | maxillary agenesis | mandibular agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Apert syndrome | unilateral agenesis | bilateral agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Apert syndrome | monomaxillary agenesis | bimaxillary agenesis | Permanent tooth agenesis distribution | RR 2.67 [1.08, 6.6] GRADE not reported Studies not reported |
| Patients with Apert syndrome | single-tooth agenesis | multiple-tooth agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Crouzon syndrome | left-sided agenesis | right-sided agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Crouzon syndrome | maxillary agenesis | mandibular agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Crouzon syndrome | unilateral agenesis | bilateral agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Crouzon syndrome | monomaxillary agenesis | bimaxillary agenesis | Permanent tooth agenesis distribution | RR 2.28 [0.99, 5.23] GRADE not reported Studies not reported |
| Patients with Crouzon syndrome | single-tooth agenesis | multiple-tooth agenesis | Permanent tooth agenesis distribution | No statistically significant difference reported; estimate not given in text (Figure S1 image not available) GRADE not reported Studies not reported |
| Patients with Apert syndrome | Male | Female | Permanent tooth agenesis prevalence | No sex differences were found; estimate not given GRADE not reported Studies not reported |
| Patients with Crouzon syndrome | Male | Female | Permanent tooth agenesis prevalence | No sex differences were found; estimate not given GRADE not reported Studies not reported |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Dalben 2006 Oral findings in patients with Apert syndrome. PMID:19089249 | 2006 | this review only | not stated | not extracted yet |
| Kakutani 2017 Evaluation of the maxillofacial morphological characteristics of Apert syndrome infants. PMID:27534905 | 2017 | this review only | not stated | not extracted yet |
| Kobayashi 2021 Craniofacial, oral, and cervical morphological characteristics in Japanese patients with Apert syndrome or Crouzon syndrome. PMID:32144423 | 2021 | this review only | not stated | not extracted yet |
| Letra 2007 Intraoral features of Apert's syndrome. PMID:17466880 | 2007 | this review only | not stated | not extracted yet |
| Reitsma 2014 Patterns of tooth agenesis in patients with crouzon or apert syndrome. PMID:23126314 | 2014 | this review only | not stated | not extracted yet |
| Stavropoulos 2011 (Apert) Dental agenesis patterns of permanent teeth in Apert syndrome. PMID:21564313 | 2011 | this review only | not stated | not extracted yet |
| Stavropoulos 2011 (Crouzon) Dental agenesis patterns in Crouzon syndrome. PMID:22372307 | 2011 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with Apert or Crouzon syndrome, no restriction on age, sex, ethnicity or country | 89 individuals with Apert syndrome and 77 with Crouzon syndrome (aged about 5 to 22 years; Brazil, Sweden, the Netherlands, Japan) |
| Intervention | Exposure: dental evaluation for presence of permanent tooth agenesis (clinical and/or radiographic) | Apert or Crouzon syndrome (dental evaluation) |
| Comparison | No comparison group | No comparison group (Crouzon versus Apert compared indirectly via RR) |
| Outcomes | Prevalence and patterns of permanent tooth agenesis | Overall prevalence 37% (Apert) and 31% (Crouzon); tooth-type and tooth-specific prevalence; TAC patterns |
| Study designs | Observational studies (case series, cross-sectional, longitudinal; retrospective or prospective); case reports excluded | 7 observational studies (case series or cross-sectional) |
| Timing | Not specified | Not specified |