Non-Cochrane · intervention · PM41034633
Parotid gland sialolithiasis: a comprehensive systematic review and meta-analysis : Title page.
Salzano Giovanni, Scocca Veronica, Committeri Umberto, et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026 · PubMed · doi:10.1007/s00405-025-09697-y
Findings
Population Patients with parotid sialolithiasis
13 findings
| Pure endoscopy | None (single-arm pooled proportion) | Complication rate | Proportion 0.20 [0.06, 0.50] GRADE not reported 3 studies · 44 participants |
| Pure endoscopy | None (single-arm pooled proportion) | Stone-free rate | Proportion 0.83 [0.44, 0.97] GRADE not reported 4 studies · 70 participants |
| Pure endoscopy | None (single-arm pooled proportion) | Symptom improvement rate | Proportion 0.95 [0.07, 1.00] GRADE not reported 2 studies · 34 participants |
| Pure endoscopy | None (single-arm pooled proportion) | Mean stone size | Mean (mm) 5.88 [4.41, 7.36] GRADE not reported Studies not reported |
| Intraoral or transfacial endoscopy-assisted stone removal | None (single-arm pooled proportion) | Complication rate | Proportion 0.24 [0.14, 0.37] GRADE not reported 24 studies · 775 participants |
| Intraoral or transfacial endoscopy-assisted stone removal | None (single-arm pooled proportion) | Stone-free rate | Proportion 0.93 [0.90, 0.96] GRADE not reported 25 studies · 763 participants |
| Intraoral or transfacial endoscopy-assisted stone removal | None (single-arm pooled proportion) | Symptom improvement rate | Proportion 0.91 [0.86, 0.94] GRADE not reported 23 studies · 746 participants |
| Intraoral or transfacial endoscopy-assisted stone removal | None (single-arm pooled proportion) | Mean stone size | Mean (mm) 7.80 [7.10, 8.50] GRADE not reported Studies not reported |
| CT navigation-assisted combined approach | None (single-arm pooled proportion) | Stone-free rate | Proportion 0.80 [0.62, 0.91] GRADE not reported 3 studies · 29 participants |
| Extracorporeal shock wave lithotripsy (ESWL) | None (single-arm pooled proportion) | Complication rate | Proportion 0.22 [0.02, 0.83] GRADE not reported 4 studies · 137 participants |
| Extracorporeal shock wave lithotripsy (ESWL) | None (single-arm pooled proportion) | Mean stone size | Mean (mm) 6.29 [6.01, 6.57] GRADE not reported Studies not reported |
| Extracorporeal shock wave lithotripsy (ESWL) | None (single-arm pooled proportion) | Symptom improvement rate | Proportion 0.86 [0.72, 0.93] GRADE not reported 8 studies · 401 participants |
| Extracorporeal shock wave lithotripsy (ESWL) | None (single-arm pooled proportion) | Stone-free rate | Proportion 0.58 [0.44, 0.71] GRADE not reported 9 studies · 460 participants |
Included primary studies 42
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Almeida-Parra F 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Anicin A 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Capaccio P 2004 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Capaccio P 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Carroll WW 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Desmots F 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Escudier MP 2003 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Escudier MP 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Foletti JM 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Foucque O 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gaffuri M 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hafrén L 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Joshi AS 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| K ¨ulkens C 2001 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Karavidas 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Klein H 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Koch M 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kondo N 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Konstantinidis I 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kopec T 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kulkens C 2001 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lafont J 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Magdy EA 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| McGurk M 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| McGurk M 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mikolajczak S 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nahlieli O 2002 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nguyen HL 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ong AA 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ottaviani F 1997 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Overton A 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Rotnágl J 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Saga-Gutierrez C 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Samani M 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Schmitz S 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Singh PP 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Singh PP 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tanenbaum Z 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Xie L 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zenk J 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zheng DN 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zheng LY 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with parotid sialolithiasis (no age or type restriction) | Patients with parotid sialolithiasis (n=1,559) |
| Intervention | Pure endoscopy; intraoral or transfacial endoscopy-assisted; CT navigation-assisted; endoscopic YAG-holmium laser; ESWL | Pure endoscopy (n=121); endoscopy-assisted intraoral/transfacial (n=774); CT navigation-assisted (n=29); ESWL (n=568); endoscopy plus ESWL (n=53); YAG-holmium laser (n=21) |
| Comparison | Between treatment modalities (single-arm studies also eligible) | None (single-arm pooled analyses) |
| Outcomes | Stone-free rate; symptom improvement; complication rate; stone location and size; sialoadenectomy | Stone-free rate; symptom improvement rate; complication rate; mean stone size |
| Study designs | Retrospective and prospective cohorts, case-control, cross-sectional studies and RCTs | Observational studies only; no RCTs (n=42) |
| Timing | Not specified | Mean follow-up 3 months to 150 months |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | No | no |
| 7List of excluded studies with reasonscritical | Yes | No | no |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | NRSI: Partial Yes · RCT: N/A | NRSI: Partial Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | NRSI: Yes · RCT: N/A | NRSI: Yes | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | No | no |
| 16Conflicts of interest reported | No | No | yes |
| Overall | Moderate | Critically Low | no |